Dietary Cholesterol and Myocardial Infarction in the Million Veteran Program
Nguyen XT, Li Y, Nyaeme MS, Panigrahy N, Houghton S, Ivey KL, Shiekh S, Willett WC, Hu FB, Gaziano JM, Wilson PWF, Cho K, Djousse L, VA Million Veteran Program
Journal of the American Heart Association · 1 citation
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Veterans Affairs
- Government
- BLRD VA
- Government
- CSRD VA
- Grants
- U.S. Department of Veterans Affairs (I01 BX003340); U.S. Department of Veterans Affairs (HSR RES 13-457); U.S. Department of Veterans Affairs (I01-BX004821); U.S. Department of Veterans Affairs (I01 CX001025); U.S. Department of Veterans Affairs (RES 13-457)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-02-08 · J Am Heart Assoc · vol. 14 · issue 4 · p. e036819
- Publisher
- Wiley
- Cited
- 2 citations · more than 82% of similar papers · 1.8× the field average
- References
- 36 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins · Fatty Acid Research and Health
- Keywords
- Medicine, Myocardial infarction, Cholesterol, Internal medicine, Relative risk, Coronary artery disease, Cohort, Cohort study, High cholesterol, Incidence (geometry), Cardiology, Confidence interval
- MeSH
- humans, myocardial infarction, cholesterol, dietary, incidence, risk assessment, risk factors, prospective studies, databases, factual, aged, middle aged, veterans, united states, female, male
14 authors
From US
- Xuan‐Mai T. Nguyen · correspondingUniversity of California, Los Angeles; VA Boston Healthcare System
- Yanping LiHarvard University; VA Boston Healthcare System
- Mark S. NyaemeUniversity of Illinois Urbana-Champaign; Illinois College
- Neha Panigrahy
- Serena C. HoughtonVA Boston Healthcare System
- Kerry Lee IveyVA Boston Healthcare System
Abstract
Background
Coronary artery disease is a leading cause of morbidity and mortality in the United States. Coronary artery disease can lead to major complications including myocardial infarction (MI). The association of dietary cholesterol with coronary artery disease remains inconsistent. We examined the relation of dietary cholesterol with the incidence of MI among participants of the Million Veteran Program.
Methods and results
The Million Veteran Program is a prospective cohort database collecting genetic and nongenetic factors influencing chronic diseases. We analyzed data from 180 156 veterans with complete information on relevant dietary intake. The association between dietary cholesterol and MI risk was assessed using both linear and nonlinear models. Statistical significance was determined using the Wald test for linear trends and the likelihood ratio test for nonlinearity, alongside comparisons between high (≥300 mg/d) and low (300 mg/d of cholesterol had a 15% increased MI risk compared with those consuming less (RR, 1.15 [95% CI, 1.06-1.25]).
Conclusions
We found that dietary cholesterol intake was linearly associated with greater risk of MI. These findings contribute to the growing literature highlighting the impact dietary cholesterol has on cardiovascular health. Reductions in cholesterol intake, which can be achieved by decreasing the intake of meat and eggs, may reduce the risk of incident MI.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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