Effect of egg consumption on health outcomes: An updated umbrella review of systematic reviews and meta-analysis of observational and intervention studies
Formisano E, Lopes Neri LC, Caffa I, Borgarelli C, Ferrando MR, Proietti E, Turrini F, Martini D, Angelino D, Tagliabue A, Pisciotta L
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2025-01-04 · Nutr Metab Cardiovasc Dis · vol. 35 · issue 5 · p. 103849
- Publisher
- Elsevier BV
- Cited
- 10 citations · more than 90% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 71 works
- Access
- Open access (hybrid journal) · OTHER-OA
- Research areas
- Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Consumer Attitudes and Food Labeling
- Keywords
- Dyslipidemia, Medicine, Observational study, Meta-analysis, Systematic review, Internal medicine, Environmental health, MEDLINE, Obesity, Biology
- MeSH
- humans, neoplasms, risk assessment, risk factors, risk reduction behavior, health status, nutritive value, eggs, adult, middle aged, female, male, recommended dietary allowances, protective factors, biomarkers, observational studies as topic, diet, healthy
11 authors
From IT
- Elena FormisanoOspedale Policlinico San Martino; University of Genoa
- Lenycia de Cassya Lopes NeriUniversity of Pavia
- Irene CaffaOspedale Policlinico San Martino; University of Genoa
- Consuelo BorgarelliUniversity of Genoa
- Maria Regina FerrandoUniversity of Genoa
- Elisa ProiettiUniversity of Genoa
Abstract
Aims
To evaluate the effect of egg consumption on health outcomes.
Data synthesis
A systematic search in PubMed, Scopus, Lilacs, and Web of Science was developed using terms ("egg consumption" or "egg intake") and ("health" or "chronic diseases" or "diabetes" or "cancer" or "cholesterol" or "dyslipidemia"), and meta-analyses of observational or interventional studies published since January 2020 were included. The studies' quality was evaluated through AMSTAR-2 and NutriGrade, and the strength of evidence according to sample size, heterogeneity, and quality of articles. Fourteen meta-analyses were included (10 observational, 4 interventional studies). The wide range of outcomes, with substantial variability and high heterogeneity, indicated a lack of robust evidence. The overall quality of studies was critically low. The level of evidence was very weak for all the significant associations: risk of heart failure (RR 1.15; 95%CI: 1.02-1.30), cancer mortality (RR 1.13; 95%CI 1.06-1.20), higher levels of LDL cholesterol (WMD 7.39; 95%CI 5.82-8.95), total cholesterol (WMD 9.12; 95%CI 7.35-10.89), and apolipoprotein B-100 (WMD 0.06; 95%CI 0.03-0.08). Conversely, egg intake has been weakly associated with improvements in HDL cholesterol (WMD 1.37; 95%CI 0.49-2.25), apolipoprotein A1 (WMD 0.03; 95%CI 0.01-0.05), and growth parameters in children (WMD 0.47; 95%CI 0.13-0.80). No evidence of association was found among all cardiovascular outcomes and all-cause mortality risk between high vs. low egg consumption.
Conclusion
Due to the critically low strength of studies, insufficient evidence is available to discourage egg consumption, suggesting eggs can be part of a healthy diet.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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