Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis
Guo J, Wang Y, He W, Lou M, Peng Y, Shi H, Lian A
Brain & development · 2 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Natural Science Foundation of Hunan Province
- Government
- Hunan Provincial Natural Science Foundation
- Grants
- Natural Science Foundation of Hunan Province (2023JJ40356); Natural Science Foundation of Hunan Province (2023JJ40354); Natural Science Foundation of Hunan Province (2023JJ40358)
Based on 2 listed funder(s).
Publication
- Published
- 2025-02-14 · Brain Dev · vol. 47 · issue 2 · p. 104321
- Publisher
- Elsevier BV
- Cited
- 2 citations · more than 40% of similar papers · 0.4× the field average
- References
- 39 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nuclear Receptors and Signaling · Genomics, phytochemicals, and oxidative stress · Child Nutrition and Feeding Issues
- Keywords
- Meta-analysis, Sulforaphane, Autism spectrum disorder, Psychology, Autism, Medicine, Psychiatry, Internal medicine
- MeSH
- humans, isothiocyanates, sulfoxides, autism spectrum disorder
7 authors
From CN
- Jialing GuoHunan Provincial Maternal and Child Health Hospital
- Yichao WangHunan Provincial Maternal and Child Health Hospital
- Weijun HeHunan Provincial Maternal and Child Health Hospital
- Mingxing LouHunan Provincial Maternal and Child Health Hospital
- Ying PengHunan Provincial Maternal and Child Health Hospital
- Hui ShiHunan Provincial Maternal and Child Health Hospital
Abstract
Autism spectrum disorder (ASD) has become an increasingly prominent global health issue. Sulforaphane is a phytochemical with multiple functions that target many of the same biochemical and molecular pathways (biomarkers) associated with ASD. This study aimed to conduct a meta-analysis based on sulforaphane's effect on Aberrant Behavior Checklist (ABC) and Social Responsiveness Scale (SRS) in patients with ASD. We conducted comprehensive searches in the PubMed, Medline, Cochrane, EMBASE, and Web of Science databases from their inception. The modified Cochrane risk of bias tool was used to check the risk of bias of the included studies. Review Manager 5.3 software was used to conduct this meta-analysis. The results of this meta-analysis showed that sulforaphane significantly improved irritability and hyperactivity symptoms, suggesting that sulforaphane has the potential for the combined treatment of autism. Additional studies are needed to confirm and explore the effect of sulforaphane.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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