Impact of dietary magnesium intake on depression risk in American adults: a cross-sectional study of the National Health and Nutrition Examination Survey 2005-2020
Huang Y, Ruan S, Yang Y, Liang H, Chen S, Chang Q
Frontiers in nutrition · 1 citation
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- General Hospital of People’s Liberation Army
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-02-06 · Front Nutr · vol. 12 · p. 1484344
- Publisher
- Frontiers Media
- Cited
- 2 citations · more than 71% of similar papers · 1.0× the field average
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Therapeutic Uses of Natural Elements
- Keywords
- National Health and Nutrition Examination Survey, Cross-sectional study, Environmental health, Medicine, Depression (economics), Gerontology, Population
6 authors
From CN
- Yanping Huang · correspondingFujian University of Traditional Chinese Medicine
- Su RuanFujian University of Traditional Chinese Medicine
- Yang YangFujian University of Traditional Chinese Medicine
- Hui Wen LiangFujian University of Traditional Chinese Medicine
- Su ChenFujian University of Traditional Chinese Medicine
- Qing ChangFujian University of Traditional Chinese Medicine
Abstract
Introduction
Depression is a major global mental health challenge. Previous research suggests a link between magnesium consumption and depression, but the dose-response relationship remains unclear. This study investigates the relationship between dietary magnesium intake and depression risk among American adults.
Methods
Data from the 2005-2020 National Health and Nutrition Examination Survey (NHANES) were examined. Depression was measured with the Patient Health Questionnaire-9 (PHQ-9), and dietary magnesium consumption was calculated from two 24-h meal recalls. We used restricted cubic spline models, logistic regression, and sensitivity analyses to assess the connection.
Results
Among 35,252 participants (mean age: 49.5 ± 17.6 years; 49.9% women), we observed a nonlinearity in the relationship between dietary magnesium intake and depression. Below the inflection point (366.7 mg/day), the odds ratio (OR) was 0.998 (95% CI: 0.997-0.999, p p = 0.007). In participants aged ≥60 years, the association was inverse L-shaped, with magnesium intake ≥270.7 mg/day increasing depression incidence by 0.1% per 1 mg/d increase.
Conclusion
A nonlinear dose-response relationship exists between dietary magnesium intake and depression risk among US adults. Age significantly moderates this association, suggesting dietary recommendations should be tailored to different age groups.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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