Trimethylamine N-Oxide Plasma Levels Following Red Meat and Cod Fish Intake: A Pilot Crossover Trial in Hemodialysis Patients
Manhães LM, Santana L, Alves MR, Leal PM, de Velasco PC, Santana I, de Brito JS, Mafra D, Borges NA
Molecular nutrition & food research · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Grants
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/202.524/2019); Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/211.440/2019)
Based on 1 listed funder(s).
Publication
- Published
- 2025-03-13 · Mol Nutr Food Res · vol. 69 · issue 8 · p. e70031
- Publisher
- Wiley
- Cited
- 4 citations · more than 88% of similar papers · 2.4× the field average
- References
- 63 works
- Access
- Paywalled
- Research areas
- Dialysis and Renal Disease Management · Gut microbiota and health · Nutritional Studies and Diet
- Keywords
- Trimethylamine N-oxide, Crossover study, Red meat, Food science, Hemodialysis, Trimethylamine, Fish <Actinopterygii>, Medicine, Kidney disease, Internal medicine, Animal science, Chemistry, Physiology, Endocrinology, Biology, Biochemistry, Fishery, Pathology
- MeSH
- animals, gadus morhua, humans, methylamines, renal dialysis, diet, pilot projects, cross-over studies, seafood, aged, middle aged, female, male, renal insufficiency, chronic, red meat
9 authors
From BR
- Larissa de Mattos ManhãesUniversidade do Estado do Rio de Janeiro
- L. C. L. A SANTANAUniversidade do Estado do Rio de Janeiro
- Marcelo Ribeiro Alves
- Priscila Mansur LealHospital Universitário Pedro Ernesto
- Patricia Coelho de VelascoUniversidade do Estado do Rio de Janeiro
- Isabelle SantanaUniversidade do Estado do Rio de Janeiro
Abstract
Scope
The uremic toxin trimethylamine N-oxide (TMAO) accumulates in patients with chronic kidney disease (CKD) and is associated with its progression, cardiovascular disease, and other complications. The gut microbiota produces TMAO from substrates mainly found in red meat, eggs, and dairy. However, some saltwater fish also contain high levels of TMAO. Although fish consumption is generally linked to beneficial effects, its effects on CKD patients require further research.
Methods and results
This study compares the effect of red meat and cod fish intake on TMAO plasma levels in CKD patients undergoing hemodialysis (HD). Participants received a single animal protein source (red meat vs. cod fish) for lunch and dinner for four consecutive days (each intervention), with a 2-week washout period in between. TMAO plasma levels were analyzed using LC-MS/MS. All 14 patients concluded the red meat intervention, while one refused to participate in the fish intervention. No significant difference in TMAO plasma levels was found post-red meat (p = 0.21) or fish intervention (p = 0.91), as well as between groups (p = 0.43).
Conclusion
In this study, 4 days of red meat and cod fish intake did not significantly impact TMAO levels in HD patients, while other factors may be associated with their circulating levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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