Funded in part by Novo Nordisk, Novo Nordisk Fonden, Novo Nordisk Fonden (Novo Nordisk Foundation)
Optimal dietary patterns for healthy aging
Tessier AJ, Wang F, Korat AA, Eliassen AH, Chavarro J, Grodstein F, Li J, Liang L, Willett WC, Sun Q, Stampfer MJ, Hu FB, Guasch-Ferré M
Nature medicine · 168 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Health and Human Services
- Government
- U.S. Department of Agriculture
- Government
- Government of Canada
- Company
- Novo Nordisk
- Company
- Novo Nordisk Fonden
- Government
- National Institutes of Health
- Government
- Canadian Institutes of Health Research
- Government
- National Institute on Aging
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- U.S. Department of Health & Human Services | National Institutes of Health
- Government
- Gouvernement du Canada | Canadian Institutes of Health Research
- Company
- Novo Nordisk Fonden (Novo Nordisk Foundation)
- Government
- U.S. Department of Health & Human Services | National Institutes of Health (NIH)
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NHLBI NIH HHS
- Government
- NCATS NIH HHS
- Government
- NIA NIH HHS
- Grants
- National Cancer Institute (U01 CA167552); National Center for Advancing Translational Sciences (1K12TR004384); National Cancer Institute (P01 CA087969); National Heart, Lung, and Blood Institute (R01-HL034594); National Cancer Institute (UM1 CA186107); U.S. Department of Health and Human Services (UM1 CA186107); National Heart, Lung, and Blood Institute (R01 HL035464); National Center for Advancing Translational Sciences (K12 TR004384); U.S. Department of Health and Human Services (U01 CA167552); National Heart, Lung, and Blood Institute (R01-HL-088521); U.S. Department of Agriculture (58–8050-3-003); National Institutes of Health (3u01ca167552-09s1); National Institutes of Health (5r01hl035464-33); Canadian Institutes of Health Research (P01 CA87969); National Institute of Diabetes and Digestive and Kidney Diseases (U01 CA167552); Novo Nordisk Fonden (NNF23SA 0084103); U.S. Department of Health and Human Services (P01 CA87969); National Institutes of Health (3um1ca186107-03s1); National Center for Advancing Translational Sciences (UM1 CA186107); U.S. Department of Health and Human Services (R01 HL35464); National Institute of Diabetes and Digestive and Kidney Diseases (R00DK122128); National Institutes of Health (2p01ca087969-06); Canadian Institutes of Health Research (UM1 CA186107); Novo Nordisk (NNF23SA0084103); National Institutes of Health (U01-CA167552); National Institutes of Health (R01‐HL‐088521); National Institutes of Health (1K12TR004384); National Institutes of Health (P01 CA 87969); National Institutes of Health (R01 HL034594); National Institutes of Health (HL034594); National Institutes of Health (R01HL35464); National Institutes of Health (UM1‐CA‐186107); National Institutes of Health (CA-167552); National Institutes of Health (CA186107); National Institutes of Health (CA 87969); National Institutes of Health (HL088521); National Institutes of Health (HL35464); National Institute on Aging (R01 AG087356); National Institute of Diabetes and Digestive and Kidney Diseases (HL034594)
Based on 21 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-03-24 · Nat Med · vol. 31 · issue 5 · pp. 1644–1652
- Publisher
- Nature Portfolio
- Cited
- 208 citations · more than 100% of similar papers · 184.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Agriculture Sustainability and Environmental Impact
- Keywords
- Healthy aging, Gerontology, Medicine, Biology
- MeSH
- humans, diet, longitudinal studies, feeding behavior, aging, adult, aged, middle aged, female, male, surveys and questionnaires, healthy aging, diet, healthy
13 authors
From US, CA, DK
- Anne‐Julie Tessier · correspondingHarvard University; Montreal Heart Institute; Université du Québec; Université de Montréal
- Fenglei WangHarvard University
- Andres Ardisson KoratTufts University
- A. Heather EliassenBrigham and Women's Hospital; Harvard University
- Jorge E. ChavarroBrigham and Women's Hospital; Harvard University
- Francine GrodsteinRush University Medical Center
Abstract
As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from the Nurses' Health Study (1986-2016) and the Health Professionals Follow-Up Study (1986-2016), we examined the association of long-term adherence to eight dietary patterns and ultraprocessed food consumption with healthy aging, as assessed according to measures of cognitive, physical and mental health, as well as living to 70 years of age free of chronic diseases. After up to 30 years of follow-up, 9,771 (9.3%) of 105,015 participants (66% women, mean age = 53 years (s.d. = 8)) achieved healthy aging. For each dietary pattern, higher adherence was associated with greater odds of healthy aging and its domains. The odds ratios for the highest quintile versus the lowest ranged from 1.45 (95% confidence interval (CI) = 1.35-1.57; healthful plant-based diet) to 1.86 (95% CI = 1.71-2.01; Alternative Healthy Eating Index). When the age threshold for healthy aging was shifted to 75 years, the Alternative Healthy Eating Index diet showed the strongest association with healthy aging, with an odds ratio of 2.24 (95% CI = 2.01-2.50). Higher intakes of fruits, vegetables, whole grains, unsaturated fats, nuts, legumes and low-fat dairy products were linked to greater odds of healthy aging, whereas higher intakes of trans fats, sodium, sugary beverages and red or processed meats (or both) were inversely associated. Our findings suggest that dietary patterns rich in plant-based foods, with moderate inclusion of healthy animal-based foods, may enhance overall healthy aging, guiding future dietary guidelines.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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