Funded in part by Nestlé Health Science
Reduced Serum PD-L1 and Markers of Inflammation in Response to Alternate Day Fasting With a Low-Carbohydrate Intervention: A Secondary Analysis of a Single-Arm Trial
Akasheh RT, Fantuzzi G, Varady KA, Cheng TD, Kalam F
Current developments in nutrition · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Ohio State University
- Company
- Nestlé Health Science
- Government
- National Cancer Institute
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Cancer Institute (P30CA016058); Ohio State University (P30CA016058)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-02-14 · Curr Dev Nutr · vol. 9 · issue 3 · p. 104566
- Publisher
- Elsevier BV
- Cited
- 2 citations · more than 74% of similar papers · 1.1× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Keywords
- Inflammation, Medicine, Intervention (counseling), Internal medicine, Carbohydrate, Low carbohydrate, Randomized controlled trial, Endocrinology, Weight loss, Obesity
5 authors
From US
- Rand T. Akasheh · correspondingThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
- Giamila FantuzziUniversity of Illinois Chicago
- Krista A VaradyUniversity of Illinois Chicago
- Ting‐Yuan David Cheng · correspondingThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
- Faiza KalamThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Abstract
This secondary analysis aimed to examine the effect of a single-arm alternate day fasting intervention with a 30% low-carbohydrate diet on biomarkers of inflammation and immune activation in adults with obesity. A 12-week weight-loss period was followed by a 12-week weight maintenance period. Anthropometrics and blood samples were collected at baseline and weeks 12 and 24. Multiplex assay was used to measure serum biomarkers including programmed death ligand 1 (PD-L1), interleukin 8 (IL-8), IL-1 receptor antagonist (IL-1ra), chemokine ligand (CCL)2, CCL4, interferon gamma (IFnγ), IFNγ-induced protein 10 (IP-10), and cluster of differentiation 40 ligand (CD40-L). In 28 participants, body weight and fat mass decreased during the weight-loss period but stabilized during the weight maintenance period. Serum PD-L1 decreased from baseline to week 12 (P = 0.005) but not at week 24. Moreover, IL-1ra and CCL4 concentrations decreased from baseline to week 24 (P P < 0.008, respectively). Changes were not significant for in CCL2, IL-8, CD40-L, IFNγ, or IP-10. In conclusion, alternate day fasting-low carbohydrate modulates circulating immune biomarkers, which may be relevant to diabetes, cancer, and autoimmunity. This trial was registered at clinicaltrials.gov as NCT03528317 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934424/).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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