Evaluation of Yograj Guggulu, Ashwagandha Churna and Narayana Taila in management of Osteoarthritis Knee: A study in tribal dominant community
Kachare K, Makhija D, Sharma A, Sunita, Srikanth N, Sharma BS, Rana R, Tripathi A, Rao BCS, Panda P, Ekta, Naik R, Nishanth K, Shekhar Namburi UR, Tiwari V, Singh SB, Monika, Srinivas P, Sharma V, Avhad A, Sinha A, Ravte R, Lal A, Rao K, Mashram P, Doddamani SH, Gopad S, Priya, Tiwari D, Mangal A, Kumawat VB, Prameela K, Subhash, Ram J, Sahu SK, Niral S, Abhaydev
Journal of Ayurveda and integrative medicine · 2 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India
- University or hospital
- Iowa Energy Center
- Government
- Ministry of AYUSH, Government of India
- Government
- Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy
- Grants
- Iowa Energy Center (CTRI/2021/07/034964)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-03-01 · J Ayurveda Integr Med · vol. 16 · issue 2 · p. 101077
- Publisher
- Elsevier BV
- Cited
- 7 citations · more than 95% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Pharmacological Effects of Medicinal Plants · Phytochemicals and Medicinal Plants · Osteoarthritis Treatment and Mechanisms
- Keywords
- Medicine, Osteoarthritis, Traditional medicine, Physical therapy, Alternative medicine, Pathology
37 authors
From IN
- Kalpana Kachare · correspondingCentral Council for Research in Ayurvedic Science
- Deepa P MakhijaCentral Council for Research in Ayurvedic Science
- Abha SharmaCentral Council for Research in Ayurvedic Science
- Sunita SunitaCentral Council for Research in Ayurvedic Science; Ministry of AYUSH
- Narayanam SrikanthCentral Council for Research in Ayurvedic Science
- BS SharmaCentral Council for Research in Ayurvedic Science
Abstract
Background
Osteoarthritis (OA) is the most prevalent joint disease and a major cause of joint impairment and physical debility, common in elderly, women and laborious workers. The available non-steroidal anti-inflammatory drugs (NSAID) are being prescribed to manage the condition; however, newly discovered alternatives are looked upon by the practitioners. Thus, the study was aimed to provide an effective and safer alternative through Ayurveda for the management of OA.
Objective
To document the role of the selected Ayurveda formulations in the management of OA and to assess the tolerability of the formulations.
Material and methods
It was an open-label, multicentric, single-arm, prospective, study conducted at 14 peripheral institutes of the Central Council for Research in Ayurvedic Sciences, New Delhi. 483 participants of any gender between the age 40 to 65 years diagnosed with OA knee as per the ACR diagnostic criteria (2012) and willing to provide consent were enrolled in the study. Oral administration of Ayurvedic formulations Yograj Guggulu, Ashwagandha Churna and the local application of Narayana Taila was given for 12 weeks and assessment was done by means of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Modified-CRD, Pune version Score, Visual Analogue Scale score and disease-specific symptoms on 28th, 56th, 84th and 112th day.
Results
Significant change (P<0.001) was observed in WOMAC score, VAS score and cardinal symptoms of OA knee. No adverse events reported in the study and the study drugs were well tolerated by the participants.
Conclusion
The study substantiates that administration of Yograj guggulu, Ashwagandha Churna and Narayana Taila, is well acceptable and tolerable. The interventions effectively alleviate the cardinal symptoms of OA knee.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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