Inflammatory and lipemic response to red meat intake in women with and without Rheumatoid Arthritis: a single meal study within a randomized controlled trial
Sällström T, Bärebring L, Hulander E, Gjertsson I, Winkvist A, Lindqvist HM
BMC nutrition · 1 citation
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Vetenskapsrådet
- University or hospital
- Göteborgs Universitet
- Government
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- University or hospital
- University of Gothenburg
- Nonprofit
- Magnus Bergvalls Foundation
- Government
- Swedish government under the ALF agreement
- Grants
- Vetenskapsrådet (2021-00954); Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2017-00318)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-04-11 · BMC Nutr · vol. 11 · issue 1 · p. 74
- Publisher
- BioMed Central
- Cited
- 1 citation · more than 69% of similar papers · 0.8× the field average
- References
- 73 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Rheumatoid Arthritis Research and Therapies · Nutritional Studies and Diet · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Postprandial, Medicine, Rheumatoid arthritis, Internal medicine, Meal, Lipid profile, Very low-density lipoprotein, Endocrinology, Lipoprotein, Cholesterol, Clinical nutrition, Body mass index, Insulin
6 authors
From SE
- Torsten SällströmUniversity of Gothenburg
- Linnea BärebringUniversity of Gothenburg
- Erik HulanderUniversity of Gothenburg
- Inger GjertssonUniversity of Gothenburg
- Anna WinkvistUniversity of Gothenburg
- Helen M. Lindqvist · correspondingUniversity of Gothenburg
Abstract
Background
The risk of atherosclerotic cardiovascular disease (ASCVD) is increased in Rheumatoid Arthritis (RA). Previous research has suggested that lipid metabolism is altered in RA, but research under postprandial conditions is scarce. The aim of this study was to investigate whether women with RA have a different lipemic and inflammatory response to a mixed meal containing red meat compared to women without RA.
Methods
Twenty-two women with RA, with modest disease activity, and 22 women without RA matched for age and body mass index (BMI) at the group level consumed a hamburger meal containing ca. 700 kcal (53 E% from fat, 27 E% from carbohydrate). Venous blood was sampled in the fasted state and after 30 min, 1, 2, 3 and 5 h and analysed for lipid species using nuclear magnetic resonance spectroscopy. Postprandial inflammation was measured by interleukin- 6 (IL- 6). The postprandial lipid response was calculated as the incremental area under the curve minimal value, and serial measurements were analysed by repeated measures analysis of variance. Lipid and inflammatory responses were compared by linear regression analysis, adjusted for age, BMI, physical activity, and baseline plasma concentration.
Results
Plasma concentrations of IL- 6, triglycerides (TGs) and very low-density lipoprotein (VLDL) particles increased significantly after the meal compared to baseline within both groups, but no differences were observed between groups. However, the women with RA had a less pronounced response in cholesterol carried in VLDL particles (p = 0.03) and in TGs in the subfraction of VLDL particles with highest density (p = 0.03). No association was found between the response in TGs and IL- 6.
Conclusion
This study does not provide compelling evidence for any difference in the lipemic or inflammatory response in women with RA compared with age- and BMI-matched women without RA following ingestion of a mixed, high-fat meal containing red meat. The modest disease activity in women with RA should be considered when interpreting these findings. Subtle group differences found in the lipids carried by VLDL particles warrant further investigation.
Trial registration
The PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial was registered 2020-01 - 28 at Clinicaltrials.gov (NCT04247009).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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