Efficacy of single vision spectacles combined with low-level red-light therapy in myopic amblyopia for children aged 4-8
Li L, Liao Y, Wang W, Xiong Y, Li Q, Zhang L, Wang X
Photodiagnosis and photodynamic therapy · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2025-04-17 · Photodiagnosis Photodyn Ther · vol. 54 · p. 104584
- Publisher
- Elsevier BV
- Cited
- 6 citations · more than 93% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Visual perception and processing mechanisms
- Keywords
- Medicine, Optometry, Low vision, Ophthalmology
- MeSH
- humans, amblyopia, myopia, refraction, ocular, treatment outcome, prospective studies, eyeglasses, visual acuity, child, child, preschool, female, male, low-level light therapy
7 authors
From CN
- Lin LiXuzhou Medical College
- Ya LiaoXuzhou Medical College; Xuzhou No.1 People's Hospital
- Wei WangXuzhou Medical College
- Yinghui XiongXuzhou Medical College; Xuzhou No.1 People's Hospital
- Qin LiXuzhou Medical College; Xuzhou No.1 People's Hospital
- Lin ZhangChina University of Mining and Technology
Abstract
Purpose
This study evaluated the efficacy and safety of Low-Level Red Light(LLRL) therapy for improving amblyopia and controlling myopia in children aged 4-8 years with myopic amblyopia.
Methods
A prospective clinical trial with 66 children, conducted from September 2023 to May 2024, included those with Spherical Equivalent Refraction (SER = sphere power + ½ cylinder power) ≤ -0.50 D and astigmatism ≤ 2.50 D, excluding pathological myopia cases. Participants were randomly assigned to Single Vision Spectacle (SVS) or LLRL groups. All wore SVS daily, while the LLRL group also received LLRL therapy (2.0 ± 0.5 mW, 650±10 nm) twice daily. The main outcomes included Best Corrected Visual Acuity (BCVA) and myopia progression, assessed by Axial Length(AL) and SER at the 1st, 3rd, and 6th months.
Results
At the six-month follow-up, both groups showed improved BCVA. The LLRL group's BCVA improved from 0.30 (0.20,0.40) to 0.10 (0.00, 0.30), while the SVS group improved from 0.40 (0.30, 0.40) to 0.30 (0.10, 0.40). Regarding myopia progression, there was no significant change in AL and SER in the LLRL group, while in the SVS group, AL increased from 24.01±0.70 mm to 24.21±0.67 mm, and SER changed from -2.75 (-4.50, -1.75) D to -3.75 (-5.25, -2.00) D. Changes in AL and SER at 1, 3, and 6 months were significantly lower in the LLRL group compared to the SVS group.
Conclusions
LLRL and optical correction both treat myopic amblyopia in young children. LLRL accelerates visual acuity improvement and effectively retards axial elongation, better controlling myopia progression compared to optical correction alone.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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