The impact of nut consumption on vascular endothelial function: a GRADE-assessed systematic review and meta-analysis of data from randomised controlled trials
Arabi SM, Rahnama I, Malek-Ahmadi M, Chambari M, Bahrami LS, Milkarizi N, Hatami A, Sukhorukov VN, Sahebkar A
International journal of food sciences and nutrition · 1 citation
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Russian Science Foundation
- Grants
- Russian Science Foundation (24-45-20004)
Based on 1 listed funder(s).
Publication
- Published
- 2025-05-06 · Int J Food Sci Nutr · vol. 76 · issue 4 · pp. 381–393
- Publisher
- Taylor & Francis
- Cited
- 0 citations · more than 4% of similar papers · 0.0× the field average
- References
- 57 works
- Access
- Paywalled
- Research areas
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Meat and Animal Product Quality
- Keywords
- Meta-analysis, Nut, Medicine, Randomized controlled trial, Consumption (sociology), Internal medicine
- MeSH
- endothelium, vascular, humans, nuts, diet, vasodilation, adult, randomized controlled trials as topic, pulse wave analysis
9 authors
From IR, MY, RU, CA, IN
- Seyyed Mostafa ArabiUniversity of Neyshabur; Neyshabur University of Medical Sciences
- Iman Rahnama
- Mahsa MalekahmadiImam Khomeini Hospital; Tehran University of Medical Sciences
- Mahla ChambariUCSI University
- Leila Sadat BahramiUniversity of Neyshabur; Neyshabur University of Medical Sciences
- Narges MilkariziMashhad University of Medical Sciences
Abstract
This meta-analysis aimed to evaluate the effect of nut consumption on vascular endothelial function through the conduction of a comprehensive review of randomised controlled trials. We explored the major electronic databases for published RCTs examining the repercussions of nuts consumption on vascular endothelial function indicators in adults (>18 years). We used random-effects models to compute pooled estimates of weighted mean differences and confidence intervals. The protocol of the present study was registered in the international database of systematic review protocols (CRD42023472892). Nineteen articles, comprising 21 arms, were deemed eligible. According to the pooled estimations, eating nuts significantly improved flow-mediated dilation (FMD) (weighted mean difference (WMD): 1.12%, 95% CI 0.28 to 1.97, p p = 0.04). However, findings revealed that consuming nuts had no significant impact on pulse wave velocity (PWV), the index of augmentation (AIx), or heart rate. The endothelial function was considerably enhanced by nut consumption through the improvement of FMD, while the certainty of such evidence was assessed as very low.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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