Long-Term Consumption of Ultraprocessed Foods and Prodromal Features of Parkinson Disease
Wang P, Chen X, Na M, Flores-Torres MH, Bjornevik K, Zhang X, Chen X, Khandpur N, Rossato SL, Zhang FF, Ascherio A, Gao X
Neurology · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- China Postdoctoral Science Foundation
- Government
- National Institutes of Health
- Government
- Centers for Disease Control and Prevention
- Government
- Pan American Health Organization
- Government
- National Cancer Institute
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- NINDS NIH HHS
- Grants
- National Institute of Neurological Disorders and Stroke (R01NS102735)
Based on 8 listed funder(s).
Publication
- Published
- 2025-05-07 · Neurology · vol. 104 · issue 11 · p. e213562
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 12 citations · more than 98% of similar papers · 9.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 28 works
- Access
- Open access (repository copy)
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Parkinson's Disease Mechanisms and Treatments
- Keywords
- Parkinson's disease, Term (time), Consumption (sociology), Disease, Medicine, Environmental health, Pathology
- MeSH
- humans, parkinson disease, olfaction disorders, rem sleep behavior disorder, constipation, longitudinal studies, depression, adult, aged, middle aged, female, male, prodromal symptoms
12 authors
From CN, US, BR, NL
- Peilu Wang · correspondingFudan University
- Xiao ChenHarvard University; Fudan University; Massachusetts General Hospital
- Muzi NaPennsylvania State University
- Mario H. Flores‐TorresHarvard University
- Kjetil BjørnevikHarvard University
- Xuehong ZhangHarvard University; Yale University
Abstract
Background and objectives
Consumption of ultraprocessed foods (UPFs) has been associated with a higher risk of various chronic diseases, but its relation to prodromal Parkinson disease (PD) remains unclear. We aimed to assess the association between long-term UPF consumption and nonmotor features suggestive of prodromal PD.
Methods
This longitudinal analysis included participants without a history of PD from the Nurses' Health Study and Health Professionals Follow-Up Study. UPF consumption was assessed using repeated food frequency questionnaires (1984-2006) and grouped based on Nova classification. Participants provided data on probable REM sleep behavior disorder (pRBD) and constipation in 2012. Between 2014 and 2015, a subset of participants provided data on 5 additional nonmotor features, including hyposmia, impaired color vision, excessive daytime sleepiness, body pain, and depressive symptoms. The primary outcome was the combination of all 7 prodromal features and further categorized as 0 (reference), 1, 2, and ≥3 features. The secondary outcomes were all features except constipation, a combination of 3 commonly recognized features (constipation, pRBD, and hyposmia), and individual features. Multinomial logistic regression was used to estimate the association of UPF consumption with the combination of prodromal features. The association between UPF consumption and each individual feature was further examined using logistic regression.
Results
The study analyzed 42,853 participants (25,095 women [58.6%]; mean [SD] age, 47.8 [5.2] years). Comparing extreme quintiles of UPF consumption, the multivariable-adjusted odds ratio (OR) for having ≥3 vs 0 prodromal features was 2.47 (95% CI 1.89-3.23, ptrend ptrend = 0.0009) for baseline intake. Similar results were observed for combinations of all features except constipation (OR 2.00, 95% CI 1.29-3.11, ptrend ptrend = 0.008). In addition, higher UPF consumption was associated with increased odds of individual prodromal features, including pRBD, constipation, body pain, and depressive symptoms.
Discussion
Long-term UPF consumption was positively associated with nonmotor prodromal PD features. More studies are warranted to confirm whether lowering UPF consumption may prevent the occurrence of nonmotor symptoms that often precede PD diagnosis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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