Effect of repeated Low-Level red light therapy on axial length in myopic individuals: predictors for a good response
Kang D, Yuan L, Feng J, Yu R, Grzybowski A, Jin K, Sun W
BMC ophthalmology · 8 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (82201195); National Natural Science Foundation of China (82201197)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-05-07 · BMC Ophthalmol · vol. 25 · issue 1 · p. 273
- Publisher
- BioMed Central
- Cited
- 8 citations · more than 96% of similar papers · 4.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Ocular Surface and Contact Lens
- Keywords
- Medicine, Ophthalmology
- MeSH
- humans, myopia, refraction, ocular, treatment outcome, intraocular pressure, visual acuity, adult, middle aged, female, male, young adult, axial length, eye, low-level light therapy
7 authors
From CN
- Daohuan KangChildren's Hospital of Zhejiang University
- Lu YuanChildren's Hospital of Zhejiang University
- Jia Hui FengChildren's Hospital of Zhejiang University
- Rui YuChildren's Hospital of Zhejiang University
- Andrzej E. Grzybowski
- Kai Pu Jin · correspondingSecond Affiliated Hospital of Zhejiang University
Abstract
Purpose
This study aimed to investigate the effects of Repeated Low-Level Red Light (RLRL) therapy on axial length (AL) in myopic individuals and to identify key predictors for a good response to the treatment, with a focus on baseline ocular characteristics and treatment compliance.
Methods
A total of 91 participants were enrolled, with 50 classified in the poor responders' group and 41 in the good responders' group. Baseline characteristics, including age, gender, pupil constriction diameter (PCD), intraocular pressure (IOP), spherical equivalent refraction (SER), AL, corneal curvature (ACC), and choroidal thickness (CT) were recorded. Compliance and AL changes were tracked over one year. Univariable and multivariable analyses identified factors associated with AL changes.
Results
Good responders' group showed a significant AL reduction (-0.29 ± 0.16 mm, p < 0.001), while poor responders' group had an increase (+ 0.23 ± 0.12 mm, p < 0.001). Good responders' group had lower initial SER (-4.15 ± 2.87 D vs. -2.62 ± 1.80 D, p = 0.004) and longer AL (24.76 ± 1.21 mm vs. 24.15 ± 0.99 mm, p = 0.010). Both groups showed CT changes (p < 0.001), with greater increases in good responders. Univariable analysis identified initial AL and SER as predictors of a good response (both p < 0.001). Compliance showed a trend toward significance in multivariable analysis (β = -0.196, p = 0.052).
Conclusion
Longer baseline AL and lower SER are key predictors of a good response to RLRL therapy. Moreover, treatment compliance showed a trend toward significance, emphasizing its crucial role in achieving optimal outcomes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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