Establishment and validation of a prognostic model for controlling adolescents' myopia progression through repeated low-level red-light therapy
Yang Y, Bai G, Wang S, Wei R
American journal of translational research · 1 citation
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- General Hospital of People’s Liberation Army
Based on 1 listed funder(s).
Publication
- Published
- 2025-01-01 · Am J Transl Res · vol. 17 · issue 4 · pp. 2730–2742
- Publisher
- e-Century Publishing Corporation
- Cited
- 2 citations · more than 78% of similar papers · 1.3× the field average
- References
- 35 works
- Access
- Free to read
- Research areas
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinopathy of Prematurity Studies
- Keywords
- Medicine
1 author
From CN
- Yuan Yang · correspondingCangzhou Central Hospital; Tianjin Medical University Eye Hospital; Tianjin Medical University
Abstract
Background/purpose
Repeated low-level red-light (RLRL) therapy has emerged as a possible intervention to control myopia progression. This study aimed to establish and validate a prognostic model for controlling adolescents' myopia progression with RLRL therapy, considering demographic, lifestyle, and ophthalmic parameters.
Methods
A retrospective cohort study was conducted on adolescent myopic patients admitted to Cangzhou Central Hospital from January 2022 to June 2023. Patients were divided into a control group and an RLRL treatment group based on their treatment method. Various demographic, lifestyle, and ophthalmic parameters were assessed to identify predictors for treatment response. A comprehensive evaluation using logistic regression and nomogram analysis was performed to identify significant factors associated with treatment outcomes.
Results
The study included a total of 145 patients, comprising 82 in the control group and 63 in the RLRL group. RLRL therapy demonstrated significantly better effectiveness in controlling myopia progression, with a reduction of -0.62 ± 0.24 D in the RLRL group compared to -0.75 ± 0.36 D in the control group (P=0.010). Furthermore, the RLRL group exhibited improved visual acuity (logMAR) of 0.12 ± 0.06 compared to 0.15 ± 0.07 in the control group (P=0.015). Moreover, baseline demographic and ophthalmic characteristics showed significant associations with treatment outcome, emphasizing the multifaceted nature of myopia response to RLRL therapy. The nomogram analysis demonstrated high predictive performance, with an AUC of 0.994.
Conclusion
This study demonstrates the effectiveness and safety of RLRL therapy in controlling myopia progression among adolescents. The establishment of a prognostic model incorporating demographic, lifestyle, and ophthalmic factors offer a promising approach for predicting treatment outcome.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.