A randomized controlled cross-over trial of differences in acute effects on serum metabolites from isocaloric meals based on red meat, fatty fish, or soy protein
Lindqvist HM, Hulander E, Bärebring L, Gjertsson I, Winkvist A
European journal of nutrition · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Vetenskapsrådet
- University or hospital
- Göteborgs Universitet
- University or hospital
- University of Gothenburg
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-05-26 · Eur J Nutr · vol. 64 · issue 5 · p. 187
- Publisher
- Springer Science+Business Media
- Cited
- 5 citations · more than 83% of similar papers · 1.7× the field average
- References
- 37 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet · Fatty Acid Research and Health
- Keywords
- Metabolite, Postprandial, Food science, Red meat, Soy protein, Meal, Plant protein, Chemistry, Fish meal, Biology, Biochemistry, Endocrinology, Fish <Actinopterygii>, Insulin
- MeSH
- animals, humans, arthritis, rheumatoid, methylamines, creatinine, dietary fats, dietary proteins, soybean proteins, diet, cross-over studies, postprandial period, adult, aged, middle aged, female, meals, red meat
5 authors
From SE
- Helen M. Lindqvist · correspondingUniversity of Gothenburg
- Erik HulanderUniversity of Gothenburg
- Linnea BärebringUniversity of Gothenburg
- Inger GjertssonSahlgrenska University Hospital; University of Gothenburg
- Anna WinkvistUniversity of Gothenburg
Abstract
Purpose
Reducing red meat intake in the Western diet is beneficial for health and the environment. However, red meat is nutrient-rich, so understanding the impact of substituting it with other protein sources such as fish or plant-based proteins is essential, especially for vulnerable groups like the elderly and those with chronic diseases. The purpose of this study was to study the postprandial response in serum metabolites in women with Rheumatoid Arthritis (RA) after intake of red meat, fatty fish, and soy protein.
Methods
Women with RA (n = 24) consumed isocaloric meals that included burgers made from either red meat, fatty fish, or soy protein in a crossover design. Blood samples were taken in fasting state before the meal (0 h) and at intervals up to 5 h after eating. Nuclear Magnetic Resonance (NMR) analysis quantified serum metabolites, and multivariate models and univariate statistics were applied to compare postprandial metabolite changes across protein sources.
Results
Postprandial metabolite patterns varied significantly by protein type. The fatty fish meal led to a faster and higher increase in metabolites, including creatinine, isoleucine, valine, and trimethylamine N-oxide, compared to red meat. Unidentified lipids also differed. However, metabolite patterns after soy protein were similar to those after red meat.
Conclusion
This postprandial crossover trial found that intake of fatty fish lead to a quicker and more pronounced increase in key blood concentrations of metabolites compared to red meat. However, metabolite profiles in serum based on NMR-analysis were similar after intake of soy protein compared to red meat.
Trial registration
The PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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