Funded in part by Taisho Toyama Pharmaceutical Company, Taisho Pharmaceutical Co., Ltd., Taisho Pharmaceutical (Japan)
The Effects of Creatine Monohydrate Supplementation on Recovery from Eccentric Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial Considering Sex and Age Differences
Yamaguchi S, Inami T, Nishioka T, Morito A, Ishiyama K, Murayama M
Nutrients · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Keio University
- Company
- Taisho Toyama Pharmaceutical Company
- Company
- Taisho Pharmaceutical Co., Ltd.
- Company
- Taisho Pharmaceutical (Japan)
- Grants
- Taisho Toyama Pharmaceutical Company (H11PA22111)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-05-23 · Nutrients · vol. 17 · issue 11 · p. 1772
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 10 citations · more than 94% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Muscle metabolism and nutrition · Sports Performance and Training
- Keywords
- Delayed onset muscle soreness, Medicine, Placebo, Eccentric, Creatine, Creatine Monohydrate, myalgia, Randomized controlled trial, Physical therapy, Population, Muscle damage, Placebo-controlled study, Eccentric exercise, Muscle fatigue, Internal medicine, Physical medicine and rehabilitation, Double blind, Electromyography
- MeSH
- muscle, skeletal, humans, creatine, exercise, double-blind method, age factors, sex factors, recovery of function, muscle fatigue, muscle contraction, dietary supplements, adult, female, male, young adult, myalgia
6 authors
From JP
- Shota YamaguchiKeio University
- Takayuki Inami · correspondingKeio University
- Takuya NishiokaKeio University
- Akihisa MoritoTaisho Pharmaceutical (Japan)
- Kaho IshiyamaTaisho Pharmaceutical (Japan)
- Mitsuyoshi MurayamaKeio University
Abstract
Background/Objectives: In this study, we aimed to examine the effect of creatine monohydrate (CrM) supplementation on recovery from eccentric exercise-induced muscle damage (EIMD) in diverse populations, including different sexes and age groups. EIMD decreases maximal voluntary contraction (MVC), restricts the range of motion (ROM), and increases muscle stiffness and delayed-onset muscle soreness, all of which negatively impact athletic performance. Therefore, developing effective recovery strategies is essential. Methods: A double-blind, randomized, placebo-controlled trial was conducted with 40 healthy male and female participants. After 33 days of supplementation with either CrM or placebo (crystalline cellulose), the participants performed eccentric exercises. Recovery indices, including MVC, muscle stiffness, subjective muscle extensive soreness, fatigue, and upper arm circumference, were measured at baseline, immediately after exercise, 48 h post-exercise, and 96 h post-exercise. Results: The creatine supplementation group (CRE) demonstrated a significantly quicker recovery of MVC than the placebo group (PLA). Furthermore, reductions in shear modulus and muscle fatigue were observed in the CRE group. Notably, females in the CRE group exhibited a significant suppression of post-exercise edema, suggesting a sex-specific response. Conclusions: These findings indicate that CrM supplementation may enhance recovery from EIMD, contributing to the maintenance of muscle function and the reduction of discomfort after exercise. CrM has the potential to serve as a practical nutritional strategy to promote recovery, not only for athletes, but also for a broader population.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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