L-type association between magnesium intake and human papillomavirus infection in US adult women: based on NHANES 2003-2016 data
Chen H, Chen X, Chen Y, Tang L, Shi WJ, Ou YH
Frontiers in nutrition · 0 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Centers for Disease Control and Prevention
- Government
- Basic and Applied Basic Research Foundation of Guangdong Province
- Grants
- National Natural Science Foundation of China (82201871)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-05-30 · Front Nutr · vol. 12 · p. 1594489
- Publisher
- Frontiers Media
- Cited
- 1 citation · more than 62% of similar papers · 0.5× the field average
- References
- 70 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Preterm Birth and Chorioamnionitis · Bone health and osteoporosis research
- Keywords
- National Health and Nutrition Examination Survey, Human papillomavirus, Medicine, Association (psychology), Internal medicine, Physiology, Environmental health, Population, Psychology
6 authors
From CN
- Haiwei ChenSecond Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Xiaotong ChenSecond Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Yuling ChenSecond Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Lixin TangSecond Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Wenjing Shi · correspondingSecond Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
- Yong-jun Ou · correspondingSecond Affiliated Hospital of Guangzhou Medical University; Guangzhou Medical University
Abstract
Background
In the post-vaccine era, adjusting living habits and diet structure has become a new way to prevent Human papillomavirus(HPV). Although dietary factors have received much attention, the association of dietary magnesium with HPV infection remains understudied.
Method
Using NHANES cross-sectional data from 2003 to 2016, this study analyzed the relationship between magnesium intake and HPV infection in 7,246 women aged 18-59 years. Weighted logistic regression and subgroup analysis assessed independent links, while curve fitting and threshold analysis defined dose response and saturation.
Result
A significant negative correlation was observed between magnesium intake and the risk of HPV infection. After comprehensive adjustment for potential confounding factors, individuals in the highest quartile of magnesium intake exhibited a statistically significant 29.7% reduction in the risk of HPV infection for each additional unit, compared to those in the lowest quartile (CI:0.554-0.894, p = 0.005). Besides, using smooth curve fitting and threshold analysis, we found an L-shaped dose response between magnesium intake and HPV risk. Below 401 mg/day of magnesium, increased intake is inversely correlated with HPV infection risk. Above this threshold, further increases plateaued in risk reduction.
Conclusion
Moderate magnesium intake has a protective effect against HPV infection. Rationally increasing magnesium intake through dietary channels is expected to serve as an effective preventive measure against HPV infection.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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