Early changes in choroidal thickness and ocular biometry in predicting who will achieve full myopia control with repeated low-level red light therapy
Chen Y, Li M, Shang X, Li G, Zhao Z, Li P, Liu Y, Xiong R, Lai M, Wang Y, He M, Zhu Z
Photodiagnosis and photodynamic therapy · 2 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- University Grants Committee
- Grants
- University Grants Committee (P0048638); University Grants Committee (P0048181)
Based on 1 listed funder(s).
Publication
- Published
- 2025-06-16 · Photodiagnosis Photodyn Ther · vol. 54 · p. 104672
- Publisher
- Elsevier BV
- Cited
- 4 citations · more than 89% of similar papers · 2.5× the field average
- References
- 38 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Keywords
- Ophthalmology, Medicine, Optometry
- MeSH
- choroid, humans, myopia, photochemotherapy, biometry, child, female, male
12 authors
From HK, CN, AU
- Yanxian ChenHong Kong Polytechnic University
- Mingge LiShenzhen Sixth People's Hospital; ShenZhen People’s Hospital
- Xianwen ShangHong Kong Polytechnic University
- Guangyu LiHong Kong Polytechnic University
- Ziwei ZhaoHong Kong Polytechnic University
- Pengju LiHong Kong Polytechnic University
Abstract
Purpose
To evaluate the early predictors for achieving full myopia control with repeated low-level red light (RLRL) therapy based on two independent randomized clinical trials (RCTs).
Methods
Myopic children undergoing RLRL therapy from a multi-center RCT (training set) and a single-center RCT (validation set) were included. Full myopia control was defined as axial elongation <0.1mm/year. Variables included age, sex, baseline refraction, ocular parameters at baseline, 1 and 3 months (axial length [AL] and subfoveal choroidal thickness [sChT]), as well as their rates of change over the first 3 months. Four random forest models to predict full myopia control after 1 year and a logistic regression was used to estimate 2-year outcome.
Results
A total of 148 children were analyzed. The proportions of 1-year full myopia control was 54.2 % of eyes in the training set and 55.0 % in the validation set. Random forest models incorporating the rate of change in AL and sChT showed high predictive accuracy (AUC: 0.97 to 0.98) in external validation. The rate of change in AL contributed the most for model accuracy. For 2-year control, the rate of AL change had an AUC of 0.99 while the rate of change in sChT achieved only 0.69.
Conclusions
The rate of change in AL during the first three months emerged as the most important predictor for treatment outcomes at both 1-year and 2-year, rather than the change in sChT. Early monitoring of AL changes could be a valuable tool for identifying children most likely to benefit from this intervention.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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