Relationship between magnesium intake and decline in kidney function, incident chronic kidney disease and incident cardiovascular disease
Neyra JA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle AN, Fried LF, Toto RD, Moe OW, Sarnak MJ, Gutiérrez OM, Drew DA
Clinical kidney journal · 1 citation
Review labels
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How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Education, India
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Institute of Nursing Research
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NINR NIH HHS
- Government
- NIA NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NINR
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute on Aging (N01‐AG‐6–2101); National Institute on Aging (R01‐NR012459); National Institute of Diabetes and Digestive and Kidney Diseases (U54DK137307); National Institutes of Health (N01-AG-6-2103); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK133539); National Institutes of Health (U01DK12998); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092461); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK128208); National Institute of Nursing Research (R01-AG028050); National Institute of Nursing Research (N01-AG-6–2101); National Institute of Diabetes and Digestive and Kidney Diseases (DK092461); National Institute on Aging (R01-AG 028050); National Institutes of Health (N01‐AG‐6‐2106); National Institute of Nursing Research (N01-AG-6-2103); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK091392); National Institute of Nursing Research (N01-AG-6–2106); National Institutes of Health (N01-AG-6-2101); National Institutes of Health (P30 DK); National Institute on Aging (N01AG62106); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK12998); National Institute of Diabetes and Digestive and Kidney Diseases (DK-091392); National Institute of Diabetes and Digestive and Kidney Diseases (079328); National Institute on Aging (N01-AG-62103); National Institute of Nursing Research (R01-NR-012459)); National Institutes of Health (R01-AG 028050); National Institutes of Health (P30‐DK‐079328); National Institutes of Health (R01 DK091392); National Institutes of Health (R01 DK133539); National Institutes of Health (U54 DK137307); National Institutes of Health (DK091392); National Institutes of Health (R01‐NR012459); National Institutes of Health (R01 DK128208)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-05-13 · Clin Kidney J · vol. 18 · issue 6 · p. sfaf144
- Publisher
- Oxford University Press
- Cited
- 2 citations · more than 73% of similar papers · 1.0× the field average
- References
- 42 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Kidney disease, Disease, Medicine, Renal function, Magnesium, Internal medicine, Kidney, Chemistry
13 authors
From US
- Javier A. Neyra · correspondingUniversity of Alabama at Birmingham; Southwestern Medical Center; Pediatric Nephrology of Alabama; The University of Texas Southwestern Medical Center
- Ronit KatzUniversity of Washington
- Stephen B. KritchevskyWake Forest University
- Joachim H. IxUniversity of California San Diego
- Michael G. ShlipakUniversity of California, San Francisco; San Francisco VA Health Care System
- Anne B. NewmanUniversity of Pittsburgh
Abstract
Background and hypothesis
Higher magnesium (Mg) intake is associated with a lower risk of stroke, heart failure and mortality, while there are limited data with kidney disease outcomes. We hypothesized that higher dietary Mg intake would be associated with a lower incidence of cardiovascular disease (CVD), chronic kidney disease (CKD) and kidney function decline.
Methods
The Health, Aging, and Body Composition Study is an observational cohort of 3075 community-dwelling older adults. Dietary Mg intake was estimated using validated dietary surveys. Kidney outcomes included ≥30% decline in estimated glomerular filtration rate (eGFR) cystatin or incident CKD, which was defined as a subsequent eGFR 2 and at least 1 mL/min/year decline from baseline. Incident CVD was defined as incident coronary disease, heart failure, stroke or cardiovascular mortality. Multivariable Poisson regression and Cox proportional hazards models were used to evaluate the association of Mg intake with kidney and cardiovascular outcomes, respectively.
Results
After excluding missing data, 2682 individuals were available for analysis. The median daily dietary Mg intake was 278 mg/day (11.4 mmol/day) (25th-75th percentile: 214-350 mg/day). Among 1871 individuals without baseline CKD, 522 developed incident CKD, while within the whole cohort, 394 (14.7%) had a ≥30% decline in eGFR over 10 years. Higher Mg intake was independently associated with lower risk of 30% eGFR decline [incidence rate ratio (IRR) per standard deviation (SD) higher Mg intake = 0.79 (95% confidence interval 0.66, 0.93)] and with a lower risk of incident CKD [IRR per SD higher Mg intake = 0.84 (95% confidence interval 0.73, 0.96)]. Among 1968 individuals without baseline CVD, 634 developed incident CVD. There was no association between Mg intake and overall incident CVD [adjusted hazard ratio 0.98 (95% confidence interval 0.85, 1.13)].
Conclusions
Higher Mg intake was associated with a lower risk of 30% decline in eGFR and incident CKD but not with incident CVD in a large cohort of older adults. The impact of Mg supplementation on kidney outcomes warrants further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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