Efficacy and safety of eight-week therapy with Ashwagandha root extract in improvement of sexual health in healthy men: Findings of a prospective, randomized, double-blind, placebo-controlled study
Mutha AS, Mutha SA, Tejuja AH, Beldar AS, Mulay AM, Langade D
Journal of Ayurveda and integrative medicine · 2 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2025-07-01 · J Ayurveda Integr Med · vol. 16 · issue 4 · p. 101155
- Publisher
- Elsevier BV
- Cited
- 7 citations · more than 97% of similar papers · 8.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Phytochemicals and Medicinal Plants · Phytochemistry and Bioactive Compounds · Complementary and Alternative Medicine Studies
- Keywords
- Medicine, Placebo, Double blind, Randomized controlled trial, Physical therapy, Traditional medicine, Internal medicine, Alternative medicine
6 authors
From IN
- Amit Shrenikraj Mutha · correspondingGrant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals
- Sonali Amit Mutha
- Anupama Hem Tejuja
- Amit Shashikant BeldarDr. D. Y. Patil Medical College, Hospital and Research Centre
- Alok Mahendra MulayGrant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals
- Deepak LangadeD.Y. Patil University
Abstract
Background
Ashwagandha, a traditional Indian Ayurvedic remedy, an adaptogen, may improve sexual dysfunction in men and women.
Objective
This 8-week prospective, double-blind, randomized, placebo-controlled study evaluated the efficacy and safety of Ashwagandha Root Extract (ARE) on improving sexual health in healthy adult men.
Method
A total of 100 healthy men aged 30-50 years were randomly assigned to receive ARE 300 mg twice daily (n = 50), or identical placebo (n = 50) in a 1:1 ratio for 8 weeks. Study assessments such as Satisfying Sexual Events (SSEs), the Sexual Desire Inventory (SDI-2), the International Index of Erectile Function (IIEF) score, semen parameters and the Quality of Life (QOL) were done using the SF-12 tool at baseline, week 2, week 4, and week 8. Three participants from ARE and four participants from the placebo group were excluded due to follow-up loss. The efficacy analyses were done on Per-Protocol (PP) dataset of 93, whereas safety analyses were done on all 100 participants.
Results
Significant improvements were observed with ARE for semen volume (p = 0.005), sperm number (p = 0.006), sperm concentration (p = 0.007), and sperm morphology (p = 0.007). The improvement in scores was better with ARE for SDI-2 (p < 0.05), orgasm and sexual desire domains of IIEF (p < 0.05), and SF-12 (p < 0.0001). No adverse events were reported in the study.
Conclusion
Ashwagandha improved the orgasmic function, sexual desire and overall sexual satisfaction with the 8-week of oral administration. It was well tolerated as it showed no significant changes in hepatic and renal parameters in blood.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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