Efficacy comparison of atropine, orthokeratology and repeated low-level red-light therapy for myopia control in children: a systematic review and network meta-analysis
Zheng Z, Jiang X, Chen R, Dong L
The British journal of ophthalmology · 8 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Beijing Tongren Hospital
- Government
- R&D Program of Beijing Municipal Education Commission
- Grants
- Beijing Tongren Hospital (No. 2023-YJJ-ZZL-003); National Natural Science Foundation of China (82401283)
Based on 3 listed funder(s).
Publication
- Published
- 2025-07-03 · Br J Ophthalmol · vol. 109 · issue 11 · pp. 1215–1220
- Publisher
- BMJ
- Cited
- 19 citations · more than 97% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinopathy of Prematurity Studies
- Keywords
- Medicine, Orthokeratology, Meta-analysis, Randomized controlled trial, Atropine, Ophthalmology, Confidence interval, Internal medicine
- MeSH
- humans, myopia, atropine, mydriatics, refraction, ocular, treatment outcome, child, randomized controlled trials as topic, orthokeratologic procedures, low-level light therapy
4 authors
From CN
- Zetong ZhengCapital Medical University
- Xue JiangBeijing Tongren Hospital; Capital Medical University; Ministry of Industry and Information Technology
- Rongxin ChenCapital Medical University
- Dong Li · correspondingBeijing Tongren Hospital; Capital Medical University; Ministry of Industry and Information Technology
Abstract
Objectives
This study aimed to compare the efficacy of different interventions for myopia control in children, including 0.01% atropine (AP), orthokeratology (Ortho-k), and repeated low-level red-light therapy (RLRL), and their combinations by conducting a network meta-analysis.
Methods
We searched for randomised controlled trials (RCTs) in PubMed, Web of Science and Embase. The primary outcomes were the mean changes in the cycloplegic spherical equivalent (SE) and axial length (AL) at the 12-month follow-up. A Bayesian random-effects network meta-analysis was performed to estimate pooled weighted mean differences and 95% credible intervals.
Results
The analysis included 41 RCTs with 6434 eyes. Compared with the control group, all interventions were found to be effective at slowing myopia progression, combining direct and indirect evidence at the 12-month follow-up: RLRL therapy (AL -0.31 (0.39, 0.24), p<0.05; SE 0.76 (0.54, 0.98), p<0.05), 0.01% atropine (AL -0.13 (-0.20, 0.07), p<0.05; SE 0.25 (0.08, 0.42), p<0.05), Ortho-k therapy (AL -0.16 (-0.26, 0.06), p<0.05; SE 0.58 (0.05, 1.13), p<0.05) and 0.01% atropine+Ortho-k therapy (AL -0.27 (-0.38, 0.16), p<0.05; SE 0.76 (0.23, 1.31), p<0.05). The cumulative probability ranking suggested that RLRL therapy was the most effective intervention in slowing AL, followed by 0.01% atropine+Ortho-k, Ortho-k and 0.01% atropine.
Conclusions
This network meta-analysis provides evidence that RLRL, 0.01% atropine, Ortho-k and 0.01% atropine+Ortho-k are all effective in suppressing myopia progress. In terms of long-term treatment efficacy in slowing AL and SE procession, RLRL was the most effective intervention.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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