Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults
Wang B, Tan X, Yao X, Zhu Z, Zhu Z
Endocrine connections · 2 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2025-07-23 · Endocr Connect · vol. 14 · issue 8
- Publisher
- Bioscientifica
- Cited
- 1 citation · more than 64% of similar papers · 0.5× the field average
- References
- 33 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Bone health and osteoporosis research
- Keywords
- Medicine, Femoral neck, National Health and Nutrition Examination Survey, Bone mineral, Bayesian multivariate linear regression, Magnesium, Bone density, Internal medicine, Linear regression, Demography, Physiology, Endocrinology, Osteoporosis, Environmental health, Population
4 authors
From CN
- Bo WangThe First People's Hospital of Xiaoshan District, Hangzhou
- Xin TanThe First People's Hospital of Xiaoshan District, Hangzhou
- Xiaocong YaoThe First People's Hospital of Xiaoshan District, Hangzhou
- Zhongxin ZhuWenzhou Medical University; The First People's Hospital of Xiaoshan District, Hangzhou
Abstract
Background
Magnesium plays a crucial role in bone metabolism, but its relationship with bone mineral density (BMD) remains complex and potentially sex-specific. This study aimed to investigate the association between magnesium intake and femoral neck BMD in older adults.
Methods
We analyzed data from 1,343 adults aged ≥65 years in the 2017-2020 National Health and Nutrition Examination Survey, conducted by the National Center for Health Statistics in the United States. Magnesium intake was assessed using 24 h dietary recalls, and femoral neck BMD was measured by dual-energy X-ray absorptiometry. We employed weighted multivariate linear regression, subgroup analyses, and non-linear modeling techniques.
Results
The fully adjusted model (controlling for demographic, clinical, lifestyle, nutritional, and biochemical factors) revealed a significant positive association between magnesium intake and femoral neck BMD (β = 0.0020 g/cm2 per 50 mg/d increase in magnesium intake, 95% CI: 0.0001, 0.0039, P = 0.042). This association was stronger in women and participants with BMI >30 kg/m2. In men, we identified a non-linear relationship with an inflection point at 480 mg/d magnesium intake, above which the positive association diminished.
Conclusions
Our findings reveal complex, sex-specific relationships between magnesium intake and femoral neck BMD in older adults, highlighting the need for tailored dietary recommendations. The observed non-linear associations and threshold effects underscore the importance of optimal magnesium intake levels for bone health.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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