Serum albumin sensitization in children with cow's milk allergy: Clinical relevance to red meat reactions
Özdemiral C, Konuralp I, Sekerel BE
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 1 citation
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2025-07-01 · Pediatr Allergy Immunol · vol. 36 · issue 7 · p. e70157
- Publisher
- Wiley
- Cited
- 3 citations · more than 85% of similar papers · 2.0× the field average
- References
- 44 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Food Allergy and Anaphylaxis Research · Occupational exposure and asthma · Allergic Rhinitis and Sensitization
- Keywords
- Sensitization, Medicine, Allergy, Allergen, Clinical significance, Milk allergy, Cow's milk allergy, Food allergy, Immunology, Internal medicine
- MeSH
- animals, cattle, humans, food hypersensitivity, milk hypersensitivity, serum albumin, immunoglobulin e, allergens, prevalence, cross reactions, child, child, preschool, infant, female, male, red meat, clinical relevance
3 authors
From TR
- Cansu ÖzdemiralHacettepe University
- Ilteber KonuralpMiddle East Technical University
- Bülent Enis Şekerel · correspondingHacettepe University
Abstract
Introduction
Sensitization to serum albumins (SAs) in cow's milk allergy (CMA) may contribute to red meat (RM) allergy. This study evaluated the prevalence of SA sensitization, patterns of cross-sensitization, and clinical relevance to RM allergy in children with CMA.
Methods
Seventy children with CMA (58 current, 12 resolved) who underwent multiplex microarray testing were assessed for allergen sensitization profiles and reported reactions to RM.
Results
Bos d 6 sensitization was identified in 61.4% of patients, and 18% had been advised to avoid RM. Among Bos d 6-sensitized patients, 39.5% were monosensitized. Co-sensitization rates were 46.5% for Sus s 1, 25.5% for Equ c 3, 23.2% for Fel d 2, and 16.2% for Can f 3. A strong correlation was observed between Bos d 6 and Sus s 1 (r = .79), with moderate correlations to Equ c 3 and Can f 3. Hierarchical clustering grouped Bos d 6 with Sus s 1, Equ c 3, and Can f 3. While milk allergen sensitization decreased in the resolved-CMA group, Bos d 6 persisted in some patients. Although all children tolerated well-cooked RM, 10% reported allergic reactions via various exposure routes, including one patient with resolved-CMA. All RM-reactive patients were sensitized to Bos d 6.
Conclusions
Bos d 6 sensitization is common in children with CMA, yet clinical reactivity to RM is infrequent. Cultural and culinary practices may shape exposure and symptom expression, though avoidance behaviors remain common. Integrating allergen profiles into clinical care may guide risk stratification/avoidance recommendations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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