The impact of almond supplementation on oxidative stress biomarkers: a systematic review and meta-analysis of randomized control trials
Kolahi A, Movahed S, Tejareh F, Saeedy SAG, Gholizadeh M
Scientific reports · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2025-08-13 · Sci Rep · vol. 15 · issue 1 · p. 29632
- Publisher
- Nature Portfolio
- Cited
- 6 citations · more than 82% of similar papers · 1.6× the field average
- References
- 30 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Tea Polyphenols and Effects
- Keywords
- Oxidative stress, Medicine, Malondialdehyde, Glutathione peroxidase, Antioxidant, Meta-analysis, Superoxide dismutase, Randomized controlled trial, Internal medicine, Crossover study, Reactive oxygen species, Ascorbic acid, Food science, Placebo, Chemistry, Biochemistry, Pathology
- MeSH
- humans, superoxide dismutase, antioxidants, oxidative stress, dietary supplements, randomized controlled trials as topic, biomarkers, prunus dulcis
5 authors
From IR, AF
- Ahmadreza KolahiTehran University of Medical Sciences
- Samira MovahedIslamic Azad University, Science and Research Branch
- Faezeh TejarehTabriz University of Medical Sciences
- Said Abdul Ghafour SaeedyHerat University
- Mohammad Gholizadeh · correspondingNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Abstract
Oxidative stress, an imbalance between reactive oxygen species and antioxidants, contributes to chronic diseases. Almonds, rich in vitamin E, polyphenols, and monounsaturated fats, exhibit antioxidant potential, though their overall effects on oxidative biomarkers are unclear. This systematic review and meta-analysis evaluate almond supplementation's impact on these biomarkers in adults. Following PRISMA guidelines, PubMed, Scopus, and Web of Science were searched up to January 2025. Randomised controlled trials (RCTs) and crossover trials assessing biomarkers of antioxidant and oxidation status (e.g., malondialdehyde [MDA], superoxide dismutase [SOD], glutathione peroxidase [GPx], 8-hydroxy-2'-deoxyguanosine [8-OHdG], uric acid [UA]) were included. Risk of bias was evaluated using the Cochrane Tool, and random-effects models calculated weighted mean differences (WMDs) with 95% confidence intervals (CIs). Eight studies (5 RCTs, 3 crossover trials; n = 424) were included. Almond doses of > 60 g/day significantly reduced MDA (WMD = -0.46, p = 0.002), 8-OHdG (WMD = -5.83, p 60 g/day) significantly improves oxidation status by reducing MDA, 8-OHdG, and UA while enhancing SOD activity. These findings support almonds as a functional food for oxidation management. However, high heterogeneity underscores the need for standardized trials to confirm optimal dosage, duration, and conditions. Trial registration: Prospero-CRD42025646264.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.