The Associations of Dietary Copper and Magnesium Intake, Geriatric Nutritional Risk Index, and Systemic Inflammation Response Index with Stroke Risk in the Elderly
Luo B, Liu S, Zheng L, Zhang B, Zou W
Balkan medical journal · 3 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Centers for Disease Control and Prevention
Based on 1 listed funder(s).
Publication
- Published
- 2025-08-19 · Balkan Med J · vol. 42 · issue 5 · pp. 452–463
- Publisher
- Galenos Yayinevi
- Cited
- 2 citations · more than 75% of similar papers · 1.0× the field average
- References
- 2 works
- Access
- Open access (free to publish) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Trace Elements in Health · Nutritional Studies and Diet
- Keywords
- Medicine, Stroke (engine), Systemic inflammation, Index (typography), Internal medicine, Inflammation, Body mass index, Gerontology
- MeSH
- humans, inflammation, magnesium, copper, diet, geriatric assessment, nutrition surveys, logistic models, risk assessment, risk factors, cross-sectional studies, nutritional status, aged, aged, 80 and over, female, male, stroke
5 authors
From CN
- Baochun LuoHeilongjiang University of Chinese Medicine
- Sifan LiuHeilongjiang University of Chinese Medicine
- Lei ZhengHeilongjiang University of Chinese Medicine; First Affiliated Hospital of Heilongjiang University of Chinese Medicine
- Baiwen ZhangHeilongjiang University of Chinese Medicine; First Affiliated Hospital of Heilongjiang University of Chinese Medicine
- Wei ZouHeilongjiang University of Chinese Medicine; First Affiliated Hospital of Heilongjiang University of Chinese Medicine
Abstract
Background
The effects of dietary copper and magnesium intake, the geriatric nutritional risk index (GNRI), and the systemic inflammation response index (SIRI) on stroke risk in the elderly remain unclear.
Aims
To examine the relationships between dietary copper and magnesium intake, GNRI, SIRI, and stroke risk in the elderly.
Study design
Cross-sectional study.
Methods
Data from 7,157 elderly participants in National Health and Nutrition Examination Survey 2007-2016 were analyzed using multifactorial logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis, mediation analysis, and sensitivity analysis.
Results
Higher dietary copper and magnesium intake were significantly and linearly associated with lower stroke risk. SIRI was positively associated with stroke risk, while GNRI had a stable protective effect. In fully adjusted models, medium- and high-level copper and magnesium intake were positively associated with GNRI and negatively associated with SIRI. GNRI mediated 4.4% and 5.5% of the associations between copper and magnesium intake and stroke risk, respectively; SIRI mediated 3.4% and 2.9%, respectively.
Conclusion
Higher dietary copper and magnesium intake are associated with reduced stroke risk in the elderly, with GNRI and SIRI exerting modest mediating effects.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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