Association Between Magnesium Intake and Migraine Among Pre and Postmenopausal Women: A Cross-Sectional Study
Li S, Zhang J
International journal of women's health · 1 citation
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2025-08-01 · Int J Womens Health · vol. Volume 17 · pp. 2747–2758
- Publisher
- Dove Medical Press
- Cited
- 1 citation · more than 71% of similar papers · 0.7× the field average
- References
- 32 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Migraine and Headache Studies · Magnesium in Health and Disease · Menopause: Health Impacts and Treatments
- Keywords
- Medicine, Cross-sectional study, Postmenopausal women, Migraine, Association (psychology), Magnesium, Obstetrics, Internal medicine, Pathology
2 authors
From CN
- Shuang LiShaoxing People's Hospital
- Jianhua ZhangShaoxing People's Hospital
Abstract
Objective
To investigate whether menopausal status modifies the association between magnesium intake and migraine in women, hypothesizing that hormonal differences between pre-menopausal and post-menopausal women would result in differential responses to magnesium intake.
Background
While magnesium's role in migraine management has gained attention, the relationship between magnesium intake and migraine across menopausal status remains poorly studied. This is the first study to compare this association between pre-menopausal and post-menopausal women specifically.
Methods
This cross-sectional study analyzed 3,248 women from the National Health and Nutrition Examination Survey (1999-2004), which achieved interview response rates of 79-84%. Menopausal status was determined by self-report: pre-menopausal (n=1,412) or post-menopausal (n=1,836). The exposure variable was total magnesium intake (dietary plus supplements); the outcome was self-reported migraine. Covariates included age, race, education, income, body mass index, smoking, drinking, hypertension, diabetes, C-reactive protein, estimated glomerular filtration rate, and calcium intake. Non-linear relationships were examined using piecewise logistic regression.
Results
Migraine prevalence was higher in pre-menopausal (31.3%) than post-menopausal women (15.6%). A significant non-linear relationship between magnesium intake and migraine was observed in pre-menopausal women, with odds of migraine decreasing by 36.0% per unit increase in magnesium intake below 325.41 mg/day (OR: 0.64, 95% CI: 0.42-0.98, P=0.042), with no significant association above the threshold. No significant association was found in post-menopausal women. Supplementary weighted analysis validated these findings.
Conclusion
Menopausal status may modify the relationship between magnesium intake and migraine. Adequate magnesium intake may be beneficial for reducing migraine risk in pre-menopausal women. Given that over half of American adults fail to meet recommended magnesium intake, these findings have significant public health implications for targeted dietary interventions in reproductive-age women, though prospective validation is needed.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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