Effect of a Ketogenic Diet, Time-Restricted Eating or Alternate-Day Fasting on changes in ambulatory blood pressure. A sub-analysis of a randomized clinical trial
Gómez-Pérez AM, Bandera-Merchán B, Martínez-Montoro JI, Gutiérrez-Bedmar M, Díaz-Perdigones C, Subiri-Verdugo A, Moreno-Indias I, Tinahones FJ
European journal of preventive cardiology · 0 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- European Commission
- Government
- Junta de Andalucía
- Government
- Servicio Andaluz de Salud
- Government
- Instituto de Salud Carlos III
- Government
- European Regional Development Fund
- Unclassified
- Justice Programme
- Government
- Consejería de Salud y Consumo, Junta de Andalucía
- Government
- FEDER
- Government
- European Union’s Nicolas Monardes Program
- Unclassified
- Miguel Servet
- Government
- Consejería de Salud de Andalucía
- Grants
- Instituto de Salud Carlos III (CM23/00128); Instituto de Salud Carlos III (PI21/01677); Instituto de Salud Carlos III (PI24/00347); Junta de Andalucía (UMA-FEDERJA-116); Instituto de Salud Carlos III (PI18/01160); Servicio Andaluz de Salud (B-0033-2014); European Commission (PI18/01160); Instituto de Salud Carlos III (CPII21-00013); Instituto de Salud Carlos III (JR24/00006); Instituto de Salud Carlos III (CM22/00217)
Based on 11 listed funder(s).
Publication
- Published
- 2025-09-03 · Eur J Prev Cardiol
- Publisher
- Oxford University Press
- Cited
- 2 citations · more than 78% of similar papers · 1.1× the field average
- References
- 48 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Enhanced Recovery After Surgery
- Keywords
- Ambulatory, Randomized controlled trial, Ketogenic diet, Weight loss, Ketone bodies, Clinical trial
8 authors
From ES
- Ana María Gómez‐PérezInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Andalusian Centre for Nanomedicine and Biotechnology; Hospital Clínico Universitario Virgen de la Victoria; Instituto de Investigación Biomédica de Málaga; Universidad de Málaga
- Borja Bandera MerchanInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Andalusian Centre for Nanomedicine and Biotechnology; Hospital Clínico Universitario Virgen de la Victoria; Instituto de Investigación Biomédica de Málaga; Universidad de Málaga
- José Ignacio Martínez‐MontoroInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Andalusian Centre for Nanomedicine and Biotechnology; Hospital Clínico Universitario Virgen de la Victoria; Instituto de Investigación Biomédica de Málaga; Universidad de Málaga
- Mario Gutiérrez‐BedmarInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Andalusian Centre for Nanomedicine and Biotechnology; Universidad de Málaga
- Cristina María Díaz-PerdigonesInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Andalusian Centre for Nanomedicine and Biotechnology; Hospital Clínico Universitario Virgen de la Victoria; Instituto de Investigación Biomédica de Málaga; Universidad de Málaga
- Alba Subiri-VerdugoInstituto de Salud Carlos III; Andalusian Centre for Nanomedicine and Biotechnology; Hospital Clínico Universitario Virgen de la Victoria; Instituto de Investigación Biomédica de Málaga; Universidad de Málaga
Abstract
Background and aims
Obesity is a major risk factor for hypertension. The evidence on the effects of dietetic interventions to weight loss in blood pressure is scarce. Our main objective was to assess changes in blood pressure through 24-hours ambulatory blood pressure monitoring (ABPM) in different hypocaloric diets differing in their theoretical ketogenic potential.
Methods
In this single-centre, parallel-group randomized controlled trial (NCT04453150), participants with obesity (body mass index of more than 30kg/m2) were randomly assigned to one of five dietetic interventions: early time-restricted eating (eTRE), evening time-restricted eating (lTRE), modified alternate-day fasting (mADF), ketogenic diet (KD), and a control group following a standard Mediterranean diet (CG). In this subanalysis, a total of 96 participants were included and underwent 24-h ABPM before and after the intervention.
Results
All groups showed statistically significant changes in anthropometric parameters. Regarding ABPM, mADF showed greater changes with improvements in most of the ABPM parameters after the intervention. Also, lTRE showed some improvements after the intervention while the rest of the groups did not show any statistically significant change. In the linear mixed model, the mADF diet appeared to have an influence on the improvement in 24-hour systolic blood pressure.
Conclusions
Diets with different ketogenic potential aimed to weight loss have different effectiveness in reducing blood pressure. mADF was the best approach regardless of changes in body composition or ketone production.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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