Alternate-day fasting elicits larger changes in fat mass than time-restricted eating in adults without obesity - A randomized clinical trial
Derron N, Güntner AT, Weber IC, Braun J, Koska İÖ, Othman A, Mönch L, von Eckardstein A, Puhan MA, Beuschlein F, Hochuli M, Zamboni N, Guggenberger R, Gerber PA
Clinical nutrition (Edinburgh, Scotland) · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2025-09-03 · Clin Nutr · vol. 53 · pp. 212–221
- Publisher
- Elsevier BV
- Cited
- 4 citations · more than 88% of similar papers · 2.2× the field average
- References
- 65 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Enhanced Recovery After Surgery
- Keywords
- Medicine, Obesity, Fat mass, Randomized controlled trial, Intermittent fasting, Internal medicine, Clinical trial, Endocrinology
- MeSH
- adipose tissue, humans, weight loss, body mass index, fasting, body composition, energy metabolism, energy intake, time factors, quality of life, adolescent, adult, female, male, overweight, young adult
14 authors
From CH, DE
- Nina DerronUniversity Hospital Zurich
- Andreas Thomas GüntnerUniversity Hospital Zurich
- Ines C. WeberUniversity of Zurich; University Hospital Zurich
- Julia BraunUniversity of Zurich
- İlker Ö KoskaUniversity Hospital Zurich
- Alaa OthmanETH Zurich
Abstract
Background & aims
Intermittent fasting (IF) is a popular nutritional strategy for weight control and improved metabolic health, however it is unclear which type of intermittent fasting is most effective. This randomized trial directly compared short-term alternate-day fasting (ADF) and time-restricted eating (TRE) with controls in adults with overweight or a high normal weight. The aim was to compare the effects of ADF and TRE versus controls regarding whole-body fat mass loss, weight control and cardiometabolic health.
Methods
In this 4-week, parallel-arm, randomized clinical trial (February 2021-May 2022), participants aged 18-40 years with a body mass index between 23 and 30 kg/m2 were assigned to ADF (alternating fasting and ad libitum eating days), to TRE (eating only between 12:00-20:00), or control (no change in eating times). The primary outcome was change in total fat volume (assessed by whole-body magnetic resonance imaging). Secondary outcomes were subcutaneous and visceral fat mass, body weight, resting metabolic rate, biochemical markers, energy intake, activity energy expenditure and health-related quality of life.
Results
Seventy-six participants (mean [standard deviation (SD)] age, 29.6 [5.6] years; body mass index, 25.8 [2.2] kg/m2; 34 [44 %] female) were randomized to ADF (n = 26), TRE (n = 26), or control (n = 24). Seventy-five participants completed the trial (25 in ADF, 26 in TRE, 24 in control). ADF led to a greater reduction in total fat volume than control (mean difference -1059.8 cm3, 95 % CI: -1380.0 cm3 to -739.6 cm3, p 3, 95 % CI: -1013.9 to -377.6 cm3, p 3, 95 % CI: -621.3 cm3 to -106.7 cm3, p = 0.007). Energy intake was reduced by 34 % [18 %] in ADF, 15 % [21 %] in TRE and 3 % [22 %] in control. ADF, but not TRE, reduced visceral fat mass, resting metabolic rate, triiodothyronine and non-HDL cholesterol compared to controls. Only ADF increased activity energy expenditure and health-related quality of life. No serious adverse events occurred.
Conclusions
In this randomized clinical trial, ADF was more effective in reducing energy intake than TRE which has subsequent effects on fat mass and body weight. Only ADF improved several cardiometabolic risk factors.
Registration
https://clinicaltrials.gov/study/NCT04732130; Unique identifier: NCT04732130.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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