Optimizing cardiovascular health with a type 2 diabetes remission program: Ultraprocessed food-intake reduction, Mediterranean diet, chrononutrition and physical training-The DIABEPIC-2 pilot study
Dionne V, Iglesies-Grau J, Latour É, Besnier F, Gagnon C, Gayda M, Pelletier V, Selcer S, Vrinceanu T, Debray A, Tessier AJ, Juneau M, Nigam A, L'Allier PL, Bherer L
Diabetes, obesity & metabolism · 1 citation
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- The Mirella and Lino Saputo Research Chair in Cardiovascular Health and the Prevention of Cognitive Decline from Université de Montreal at the Montreal Heart Institute
Based on 1 listed funder(s).
Publication
- Published
- 2025-09-18 · Diabetes Obes Metab · vol. 27 · issue 12 · pp. 7374–7384
- Publisher
- Wiley
- Cited
- 4 citations · more than 88% of similar papers · 2.1× the field average
- References
- 33 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Diet and metabolism studies
- Keywords
- Type 2 diabetes, Cardiovascular health, Randomized controlled trial, Diabetes mellitus, MEDLINE, Physical activity
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, weight loss, exercise, caloric restriction, remission induction, fasting, feasibility studies, pilot projects, diet, mediterranean, aged, middle aged, female, male, cardiorespiratory fitness
15 authors
From CA, US
- Valérie Dionne · correspondingMontreal Heart Institute
- Josep IglésiesMontreal Heart Institute; Université de Montréal
- Élise LatourMontreal Heart Institute
- Florent BesnierMontreal Heart Institute
- Christine M. GagnonMontreal Heart Institute
- Mathieu GaydaMontreal Heart Institute; Université de Montréal
Abstract
Aims
The possibility of type 2 diabetes (T2D) remission following very-low caloric restriction has been demonstrated. However, the feasibility of T2D remission following other health behavioural interventions remains to be explored.
Materials and methods
The DIABEPIC-2 pilot study assessed the feasibility of a 6-month programme based on ultra-processed food intake reduction, a Mediterranean diet, and physical training. Also, a randomised 2:1 proportion of participants added intermittent fasting (IF) in the last 3 months. The study explored the T2D remission rate and its impact on cardiometabolic and anthropometric parameters, cardiorespiratory fitness, and quality of food matrix.
Results
Feasibility was demonstrated with a recruitment rate of 6.4 participants/month, 34 participants (81%) who completed the programme, with an 87% attendance rate (63.6 ± 9.2 years old, initial mean HbA1c of 6.7 ± 0.7%, mean T2D duration of 7.4 ± 6.7 years). At 6 months, participants had a mean weight loss of -6.8 kg (-9.3 to -4.4, p < 0.001), and 13 participants out of 34 (38%) achieved T2D remission. Overall, participants significantly improved cardiometabolic health and anthropometric parameters, cardiorespiratory fitness, and food matrix quality. Participants randomised to the IF add-on intervention group did not show significant additional improvement.
Conclusion
The DIABEPIC-2 program enabled a significant proportion of participants to achieve T2D remission and to improve their cardiovascular health; therefore, it would be relevant to confirm these results. The recruitment and visit completion rates observed in this pilot study further demonstrate its feasibility, supporting the rationale for conducting a larger randomized clinical trial.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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