Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Argeros Z, Xu X, Bhandari B, Harris K, Touyz RM, Schutte AE
Hypertension (Dallas, Tex. : 1979) · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2025-09-26 · Hypertension · vol. 82 · issue 11 · pp. 1844–1856
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 10 citations · more than 91% of similar papers · 2.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Magnesium in Health and Disease
- Keywords
- Magnesium, Randomized controlled trial, Magnesium deficiency (plants), Blood pressure, Meta-analysis
- MeSH
- humans, hypertension, magnesium, blood pressure, dose-response relationship, drug, dietary supplements, randomized controlled trials as topic
6 authors
From AU, US, CA
- Zoe ArgerosUNSW Sydney
- Xiaoyue XuUNSW Sydney; The George Institute for Global Health
- Buna BhandariFlorida State University; Florida A&M University - Florida State University College of Engineering; Harvard Global Health Institute
- Katie HarrisThe George Institute for Global Health
- Rhian M. TouyzMcGill University Health Centre
- Aletta Elisabeth SchutteUNSW Sydney; The George Institute for Global Health
Abstract
Background
There are inconsistent reports regarding the effect of magnesium intake on blood pressure (BP) across hypertensive and normotensive populations.
Methods
We performed a meta-analysis and dose-response analysis to explore the relationship between magnesium supplementation and BP in randomized-controlled trials with a duration of ≥4 weeks, using a cubic spline regression model.
Results
Thirty-eight randomized controlled trials involving 2709 participants were eligible for inclusion. Studies included an elemental magnesium dose from 82.3 mg to 637 mg with a median dose of 365 mg and a median intervention period of 12 weeks. Mean differences of changes in BP were calculated by random effects meta-analysis. Magnesium intake resulted in a reduction in systolic BP of -2.81 mm Hg (95% CI, -4.32 to -1.29) and diastolic BP by -2.05 mm Hg (95% CI, -3.23 to -0.88) compared with placebo. Hypertensive individuals on BP-lowering medication and individuals with hypomagnesemia yielded greater systolic BP reductions of -7.68 and -5.97 mm Hg, respectively (PPP≥0.20).
Conclusions
Our findings support the beneficial effect of magnesium on reducing BP among populations with hypertension and hypomagnesemia, although effects should be interpreted with caution due to high heterogeneity of studies. Larger, well-designed studies assessing higher magnesium doses are needed to refine the dose-response relationship between magnesium intake and BP and identify potential optimal supplementation strategies for subpopulations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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