Two-year outcomes of repeated red light therapy in premyopic children: sustained efficacy and rebound effects
Liu G, Li N, Rong H, Hu J, Pei E, Pazo EE, Du B, Wei R
The British journal of ophthalmology · 1 citation
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Tianjin Key Medical Discipline (Specialty) Construction Project
- Grants
- National Natural Science Foundation of China (82070929.)
Based on 2 listed funder(s).
Publication
- Published
- 2025-10-09 · Br J Ophthalmol · vol. 110 · issue 5 · pp. 536–542
- Publisher
- BMJ
- Cited
- 5 citations · more than 93% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Paywalled
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Corneal surgery and disorders
- Keywords
- Red light, Light therapy, Randomized controlled trial, Intervention (counseling), Clinical trial, Blue light
- MeSH
- choroid, humans, myopia, disease progression, tomography, optical coherence, refraction, ocular, treatment outcome, phototherapy, follow-up studies, visual acuity, time factors, child, female, male, axial length, eye
8 authors
From CN
- Guihua LiuTianjin Medical University Eye Hospital; Tianjin Medical University
- Na LiTianjin Medical University Eye Hospital; Tianjin Medical University
- Hua RongTianjin Medical University Eye Hospital; Tianjin Medical University
- Jiamei HuTianjin Medical University Eye Hospital; Tianjin Medical University
- Enpei PeiTianjin Medical University Eye Hospital; Tianjin Medical University
- Emmanuel Eric PazoTianjin Medical University Eye Hospital; Tianjin Medical University
Abstract
Background
To evaluate the long-term prevention effectiveness and rebound effect of repeated red light therapy (RRLT) in children with premyopia over 2 years.
Methods
A total of 108 premyopic children (cycloplegia spherical equivalent refraction (SER): -0.50 to +0.75 D) were enrolled and followed for 24 months. Participants were randomly assigned to the RRLT or control groups. The RRLT was administered two times per day for 3 min per session, with at least 4-hour interval. At the beginning of the second year, participants receiving RRLT were further randomised into continued treatment and washout subgroups. Axial length (AL), SER and subfoveal choroidal thickness (SChT) were measured.
Results
Over 2 years, the RRLT group showed significantly smaller AL elongation (0.26 mm; 95% CI 0.18 to 0.35 mm) and SER progression (-0.21 D; 95% CI -0.35 to -0.08 D) compared with the controls (AL: 0.43 mm; 95% CI 0.36 to 0.49 mm; SER: -0.66 D; 95% CI -0.79 to -0.52 D). The RRLT group also demonstrated significantly less SChT thinning (-2.44 µm; 95% CI -16.11 to 11.23 µm) than the controls (-44.12 µm; 95% CI -53.05 to -35.19 µm). After RRLT cessation in the second year, the washout subgroup exhibited significantly faster AL elongation and more SChT thinning than the controls, with no significant difference in SER progression.
Conclusions
The 2-year RRLT intervention effectively retarded AL elongation and SER progression in premyopic children by 0.17 mm and -0.45 D, respectively. Notably, a significant rebound effect was observed in AL growth following 1-year RRLT cessation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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