Hypohydration augments the acute increase in urinary biomarkers of kidney injury following the 100-mile Western States Endurance Run
Linder BA, Jeong S, Stute NL, El-Kurd OB, Vondrasek JD, Pasternak A, Bagley JR, Watso JC, Schlader ZJ, Babcock MC, Grosicki GJ, Robinson AT
Journal of applied physiology (Bethesda, Md. : 1985) · 6 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Heart Association
- Government
- National Institutes of Health
- Government
- Office of Environment, Health, Safety and Security
- Government
- National Institute on Aging
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute for Occupational Safety and Health
- Government
- National Center for Advancing Translational Sciences
- Government
- Office of Health and Safety
- Government
- HHS | National Institutes of Health
- University or hospital
- Auburn University Presidential Graduate Research Fellowship
- Nonprofit
- Western States Endurance Run Foundation
- Government
- NHLBI NIH HHS
- Government
- HHS | National Institutes of Health (NIH)
- Nonprofit
- American Heart Association (AHA)
- Government
- NIOSH CDC HHS
- Government
- NIA NIH HHS
- Government
- NCATS NIH HHS
- Government
- DOE | EHSS | Office of Health and Safety (OHS)
- Government
- NIDDK NIH HHS
- Government
- DOE | EHSS | Office of Health and Safety
- Grants
- Office of Environment, Health, Safety and Security (R01OH011528); National Heart, Lung, and Blood Institute (R15 HL165325); National Heart, Lung, and Blood Institute (K01HL147998); Office of Health and Safety (R01OH011528); National Institute on Aging (U54AG062319); National Institute for Occupational Safety and Health (R01 OH011528); National Heart, Lung, and Blood Institute (K01 HL160772); National Center for Advancing Translational Sciences (UL1 TR003096); National Heart, Lung, and Blood Institute (K01HL164978); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK097512); American Heart Association (23CDA1037938); National Institutes of Health (1r15hl165325-01); National Institutes of Health (K01 HL147998); National Institutes of Health (K01HL164978); National Institutes of Health (K01 HL160772); National Institutes of Health (UL1TR003096); National Institutes of Health (U54AG062319)
Based on 21 listed funder(s).
Publication
- Published
- 2025-10-20 · J Appl Physiol (1985) · vol. 139 · issue 5 · pp. 1379–1391
- Publisher
- American Physiological Society
- Cited
- 7 citations · more than 94% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 83 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Thermoregulation and physiological responses · Muscle metabolism and nutrition · High Altitude and Hypoxia
- Keywords
- Acute kidney injury, Urinary system, Creatinine, Kidney, Lipocalin, Renal function, Urine
- MeSH
- kidney, humans, dehydration, creatinine, insulin-like growth factor binding proteins, tissue inhibitor of metalloproteinase-2, physical endurance, running, adult, middle aged, female, male, acute kidney injury, biomarkers
12 authors
From US
- Braxton A. LinderIndiana University Bloomington; Auburn University
- Soolim JeongIndiana University Bloomington; Auburn University
- Nina Lawrene StuteAuburn University
- Omar B. El‐KurdSan Francisco State University
- Joseph D. VondrasekFlorida State University
- Andrew V. PasternakUniversity of Nevada, Reno
Abstract
Ultraendurance races may transiently increase acute kidney injury (AKI) risk, yet data on contributing factors are sparse. Therefore, we examined the acute effects of the Western States Endurance Run [WSER (100 miles; 161 km)] on urinary AKI biomarkers and kidney blood flow, while also assessing the influence of race pace and hydration status. Blood and urine samples were collected to assess urine specific gravity (USG), creatinine, and AKI risk [nephrin, neutrophil gelatinase-associated lipocalin (NGAL), insulin-like growth factor binding protein 7 (IGFBP7), tissue inhibitor of metalloproteinase 2 (TIMP2), and IGFBP-7·TIMP-2]. Renal blood velocity and conductance were measured via Doppler ultrasonography. Pre and post measures were obtained from 36 runners (29 males/7 females, age: 44 ± 9 yr, mean finish time: 25:45:55). Urinary AKI biomarkers increased postrace, with nephrin, IGFBP7, and IGFBP7·TIMP-2 remaining elevated after indexing to creatinine (Ps Ps ≤ 0.006). Faster race pace correlated with increases in USG (rho, ρ = 0.338, P = 0.048) and urinary creatinine (rho, ρ = 0.443, P = 0.010), but not with creatinine-indexed AKI biomarkers (Ps ≥ 0.382). Kidney blood velocity and conductance were unchanged (Ps ≥ 0.186). Finishing hydrated appears to help mitigate the transient increase in kidney injury following an ultraendurance race.NEW & NOTEWORTHY Urinary concentrations of several acute kidney injury (AKI) biomarkers increased after completing the 2023 Western States Endurance Run; however, there were no changes in renal blood flow in a subset of runners. When normalized to creatinine, several AKI biomarkers, including IGFBP7·TIMP2 (an FDA-approved biomarker of AKI), remained elevated. Notably, finishing the race euhydrated appeared to have a protective effect, mitigating increases in IGFBP7·TIMP2.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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