The impact of whole grain consumption on metabolic health: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials
Huang H, Lu W, Hu X, Chen X, Shu G, Wang J, Zhu M, Zhang Z, Zhang S
Food & function · 1 citation
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Key Scientific Research Project of Colleges and Universities in Henan Province
- Grants
- Key Scientific Research Project of Colleges and Universities in Henan Province (24A330006); National Natural Science Foundation of China (82473623)
Based on 2 listed funder(s).
Publication
- Published
- 2025-01-01 · Food Funct · vol. 16 · issue 23 · pp. 8925–8942
- Publisher
- Royal Society of Chemistry
- Cited
- 2 citations · more than 61% of similar papers · 0.6× the field average
- References
- 60 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Nutrition, Genetics, and Disease
- Keywords
- Randomized controlled trial, Systematic review, Consumption (sociology), Glycemic, Whole grains, Refined grains, Meta-analysis, Obesity
- MeSH
- humans, metabolic diseases, randomized controlled trials as topic, whole grains, systematic reviews as topic
9 authors
From CN
- Huiru HuangZhengzhou University; Zhengzhou University of Science and Technology; Zhengzhou Business University
- Wenxin LuZhengzhou University; Zhengzhou University of Science and Technology; Zhengzhou Business University
- Xiaoshuang HuZhengzhou University; Zhengzhou University of Science and Technology; Zhengzhou Business University
- Xi ChenZhengzhou University; Zhengzhou University of Science and Technology; Zhengzhou Business University
- Guangjie ShuZhengzhou University; Zhengzhou University of Science and Technology; Zhengzhou Business University
- Jian WangZhengzhou University; Zhengzhou University of Science and Technology; Zhengzhou Business University
Abstract
Background: Growing randomized controlled trials (RCTs) have demonstrated that the consumption of whole grains (WGs) can significantly improve metabolic health outcomes, including glycemic control, insulin sensitivity, and body weight management. This study aims to demonstrate the association between the consumption of WGs and metabolic health by analyzing and synthesizing the existing evidence. Methods: Five databases (PubMed, Web of Science, Embase, Scopus, and Cochrane Library) were systematically searched from their inception to March 27, 2025, to identify relevant systematic reviews and meta-analyses of RCTs investigating the association between WG consumption and metabolic health in humans. Results: A total of 25 eligible publications were included, covering 113 outcomes. A wide range of outcomes were investigated, including diabetes-related outcomes (43%), lipid metabolism (21%), anthropometric measures (12%), appetite and energy intake (5%), blood pressure (9%) and inflammatory markers (10%). Our findings demonstrated that WG consumption plays a crucial role in improving key aspects of metabolic health. Specifically, it is effective in managing diabetes, hyperlipidemia, hypertension, obesity, and inflammation, and it also notably improves appetite. Conclusions: Increasing whole grains consumption may do more good than harm for metabolic health, particularly diabetes and cardiovascular health. Further high-quality studies in different countries are needed to confirm these findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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