Replacing red and processed meat, poultry, or fish with legumes and the risk of gallbladder diseases in a large British cohort
Langmann F, Ibsen DB, Johnston LW, Perez-Cornago A, Dahm CC
European journal of nutrition · 1 citation
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- University or hospital
- Aarhus Universitet
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-11-12 · Eur J Nutr · vol. 64 · issue 8 · p. 318
- Publisher
- Springer Science+Business Media
- Cited
- 1 citation · more than 67% of similar papers · 0.5× the field average
- References
- 46 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Animal Nutrition and Physiology · Gallbladder and Bile Duct Disorders · Mycotoxins in Agriculture and Food
- Keywords
- Legume, Cohort, Fish <Actinopterygii>, Gallbladder, Cohort study
- MeSH
- animals, poultry, fishes, humans, fabaceae, gallbladder diseases, diet, proportional hazards models, risk factors, cohort studies, follow-up studies, meat, meat products, seafood, adult, aged, middle aged, female, male, red meat, united kingdom
5 authors
From DK, IT
- Fie LangmannAarhus University
- Daniel Borch IbsenAarhus University; Aarhus University Hospital; Steno Diabetes Center Aarhus
- Luke JohnstonAarhus University Hospital; Steno Diabetes Center Aarhus
- Aurora Perez‐CornagoJoint Research Centre
- Christina Catherine Dahm · correspondingAarhus University
Abstract
Purpose
Legumes are promoted as climate-friendly and healthy protein sources. This study evaluated the association between replacing red and processed meat, poultry, or fish with equal amounts of legumes and the risk of gallbladder disease.
Methods
Participants from the UK Biobank Cohort who completed two or more 24 h dietary assessments and had complete information on covariates were included. Information on age, sex, and socioeconomic and lifestyle factors were collected at recruitment, while information on dietary intake was collected using multiple 24 h dietary assessments. Information on incident gallbladder disease (defined as cholelithiasis, cholecystectomy, or cholecystitis) was collected from health registries based on ICD10-diagnosis or operation codes. The rate of developing gallbladder diseases when replacing red and processed meat, poultry, or fish with legumes was estimated using multivariable-adjusted Cox Proportional Hazards regression analyses adjusted for potential confounders.
Results
Over a median follow-up time of 10.5 (interquartile range: 10.4-10.9) years, 121,593 eligible participants provided 1,246,913 person-years of follow-up during which 3772 individuals developed gallbladder disease. Replacing 80 g/week of red and processed meat with legumes was associated with a lower rate of gallbladder disease (HR: 0.97, 95% CI 0.95; 0.98, p < 0.001). No association was found when replacing poultry or fish with legumes. Adjusting for BMI did not change the magnitude or direction of associations.
Conclusions
Replacing red and processed meat with legumes was associated with lower rates of gallbladder disease. Further research in populations with higher legume intake is warranted to confirm these findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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