Funded in part by Mushroom Council, Foundation for Meat and Poultry Research and Education
Red meat intake and its influences on inflammation and immune function biomarkers in human adults: a systematic review and meta-analysis of randomized controlled trials and observational studies
Wang Y, Uffelman CN, Hill ER, Schmok JN, Anderson NL, Reed JB, Olson MR, Campbell WW
Critical reviews in food science and nutrition · 0 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Agriculture
- Industry group
- Mushroom Council
- Industry group
- Foundation for Meat and Poultry Research and Education
- Government
- National Institutes of Health
Based on 4 listed funder(s).
Publication
- Published
- 2025-11-14 · Crit Rev Food Sci Nutr · vol. 66 · issue 14 · pp. 2765–2778
- Publisher
- Taylor & Francis
- Cited
- 3 citations · more than 70% of similar papers · 0.9× the field average
- References
- 68 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Meat and Animal Product Quality · Nutritional Studies and Diet · Sodium Intake and Health
- Keywords
- Observational study, Randomized controlled trial, Immune system, Red meat, Inflammation, Human studies
- MeSH
- humans, inflammation, leptin, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, diet, adult, adiponectin, randomized controlled trials as topic, biomarkers, observational studies as topic, red meat
8 authors
From US
- Yu Han Daisy WangPurdue University West Lafayette
- Cassi N UffelmanPurdue University West Lafayette
- Erica R. HillPurdue University West Lafayette
- Jacqueline N. SchmokPurdue University West Lafayette
- Nicole L. AndersonPurdue University West Lafayette
- Jason Brian ReedPurdue University West Lafayette
Abstract
Red meat intake (RMI) is implicated in promoting inflammation and compromising immune function. We conducted a systematic review and meta-analysis assessing how RMI influences inflammation and immune function biomarkers in adults with any health status. Twenty-two randomized controlled trials (RCTs; 1152 adults) and 10 observational studies (OBS; 438,925 adults) were included from literature published through May 2024 using PubMed, Scopus, CINAHL, and Cochrane databases. Sufficient data were obtained for meta-analyses of blood C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin. Overall, greater total RMI led to higher CRP across 18 RCTs (weighted mean difference 0.23, 95% CI 0.08-0.39). Subgroup analyses indicated similar findings for participants diagnosed with, but not without, cardiometabolic diseases; unspecified or mixed RMI, but not unprocessed RMI; studies without, but not with, energy restriction; and RMI ≥, but not Registry and registry number for systematic reviews or meta-analyses: PROSPERO CRD42021256264.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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