The association between magnesium intake and circadian syndrome among US adults attending NHANES 2005-2016
Alsheikh R, Aldulaimi H, Lathief S, Bassil M, Liu J, Shi Z
Nutrition journal · 2 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2025-11-21 · Nutr J · vol. 24 · issue 1 · p. 178
- Publisher
- BioMed Central
- Cited
- 2 citations · more than 77% of similar papers · 1.0× the field average
- References
- 55 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Clinical nutrition, Circadian rhythm, Magnesium, Association (psychology), Magnesium deficiency (plants), Blood pressure
- MeSH
- humans, chronobiology disorders, magnesium, diet, nutrition surveys, prevalence, cross-sectional studies, adult, aged, middle aged, united states, female, male
6 authors
From QA, US
- Raneem Alnassif AlsheikhQatar University
- Haneen Abdullah Taha AL-DulaimiQatar University
- Shalima LathiefQatar University
- Maya S. BassilQatar University
- Jianghong LiuUniversity of Pennsylvania
- Zumin Shi · correspondingQatar University
Abstract
Background
Circadian Syndrome (CircS) expands on metabolic syndrome (MetS) by including circadian rhythm disturbances and depression. It has been shown to be a better predictor of cardiovascular disease (CVD) than MetS. While magnesium has been linked to circadian rhythm disturbances, its association with CircS remains unclear. This study aimed to investigate the association between dietary magnesium intake and CircS using data from the National Health and Nutrition Examination Survey (NHANES).
Methods
Data from 10,486 adults aged 20 years and above who attended the 2005-2016 NHANES were analyzed in this cross-sectional study. Magnesium intake was assessed using two 24-h dietary recalls. CircS was defined based on components of MetS plus short sleep and depression, with a cut-off of ≥ 4 components. Multivariable logistic regression was used to assess the association between magnesium intake and CircS.
Results
The mean participant age was 50.3 (SD 17.6) years. The prevalence of CircS was 41.3%, decreasing from 47.3% in the lowest quartile of magnesium intake to 35.2% in the highest. After adjusting for age, gender, ethnicity, energy intake, education, and lifestyle factors, higher magnesium intake was linked to lower CircS prevalence. The adjusted odds ratios (ORs) (95% CI) across magnesium intake quartiles were: 1.00, 0.80 (0.68-0.95), 0.75 (0.64-0.87), and 0.61 (0.49-0.76) (p for trend < 0.001). The association remained significant after additional adjustment for healthy eating index. No significant interaction was found between magnesium intake and race, gender, smoking, alcohol use, or physical activity.
Conclusions
Higher magnesium intake was associated with lower CircS prevalence in U.S. adults, suggesting a potential role for magnesium in circadian health.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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