Neural, psychological, and transcriptomic predictors of short video addiction: A multi-site longitudinal study of fear of missing out and negative affect
Liu C, Li H, Shangguan Q, Zeng Y, Wang P, Zhang Z, Jin W, Wang Q
NeuroImage · 3 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Education of the People's Republic of China
- Government
- Natural Science Foundation of Tianjin City
- University or hospital
- Tianjin Normal University
- Government
- National Key Research and Development Program of China
- Government
- National Key Research and Development Program of China Stem Cell and Translational Research
- Government
- Ministry of Education of the People's Republic of China
- Government
- Tianjin Municipal Natural Science Foundation
- Grants
- Tianjin Normal University (52WZ2538); Ministry of Education of the People's Republic of China (20YJC190018); National Natural Science Foundation of China (32000786); National Key Research and Development Program of China Stem Cell and Translational Research (2024YFF1206500); Natural Science Foundation of Tianjin City (23JCYBJC00910)
Based on 8 listed funder(s).
Publication
- Published
- 2025-11-21 · Neuroimage · vol. 323 · p. 121605
- Publisher
- Elsevier BV
- Cited
- 8 citations · more than 99% of similar papers · 15.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 66 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Impact of Technology on Adolescents · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Mind wandering and attention
- Keywords
- short video addiction, fear of missing out, negative affect, gray matter volume, regional homogeneity, default mode network, frontoparietal network, ventral attention network, hippocampal morphology, gene expression, adolescent brain development
- MeSH
- brain, nerve net, humans, magnetic resonance imaging, longitudinal studies, affect, fear, adolescent, adult, female, male, young adult, transcriptome, internet addiction disorder
8 authors
From CN
- Chang LiuTianjin Normal University
- Hanbing LiTianjin Normal University
- Qianyi ShangguanTianjin Normal University
- Yuyang ZengTianjin Normal University
- Pinchun Wang · correspondingTianjin Normal University
- Zhang Zong · correspondingTianjin Normal University
Abstract
Short video addiction symptoms (SVAS) have become increasingly prevalent, yet their longitudinal neurobiological basis remains unclear. In a multi-site longitudinal study (n = 280), we examined whether baseline brain features and dispositional traits-negative affect (NA) and fear of missing out (FoMO)-predict future SVAS. Participants completed self-report measures and MRI scans at baseline, with follow-up assessments conducted after 5 months to 5 years. Behaviorally, both baseline and follow-up NA and FoMO significantly predicted SVAS. Structurally, baseline gray matter volume (GMV) in the frontal-parietal network (FPN), default mode network (DMN), and hippocampal morphological patterns predicted follow-up SVAS severity. Functionally, baseline regional homogeneity (ReHo) in the FPN, DMN, ventral attention network (VAN), and sensorimotor network (SMN) also predicted SVAS. Parallel multiple mediation analyses revealed a dissociable neural architecture: hippocampal morphological patterns predicted SVAS via the unique indirect effect of follow-up FoMO, whereas DMN functional profiles (e.g., ReHo) predicted SVAS via follow-up NA. Notably, the VAN served as an integrative hub, exerting its influence via the unique indirect effects of both follow-up NA and FoMO. Transcriptomic analyses linked SVAS-related ReHo to two gene sets, namely positively correlated (SVAS-ReHo⁺) and negatively correlated (SVAS-ReHo⁻) genes. SVAS-ReHo⁺ genes were enriched in RNA processing and vascular signaling and expressed in endothelial cells; SVAS-ReHo⁻ genes were enriched in synaptic transmission and expressed in excitatory and inhibitory neurons. Spatial-temporal patterns showed SVAS-ReHo⁺ genes were expressed in subcortical regions across adolescence, whereas SVAS-ReHo⁻ genes were prominent in cortical-limbic areas during postnatal development. Functional decoding linked SVAS-ReHo⁺ genes to sensorimotor function and metabolism, and SVAS-ReHo⁻ genes to emotion and psychiatric risk. Together, these findings highlight dissociable structural, functional, and molecular pathways through which FoMO and NA contribute to short video addiction development.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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