Nut consumption and risk of cardiovascular disease events and all-cause mortality: A systematic review and dose-response meta-analysis of prospective cohort studies
Liu M, Wang M, Fu X, He X, Wang M, Su Y, Liu G, Hu F, Zhang M, Zhao Y, Hu D
Archives of cardiovascular diseases · 1 citation
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Nonprofit
- Postdoctoral Research Foundation of China
- Government
- Shenzhen Science and Technology Innovation Program
- Government
- Basic and Applied Basic Research Foundation of Guangdong Province
- Grants
- Basic and Applied Basic Research Foundation of Guangdong Province (2022A1515010503); National Natural Science Foundation of China (82273707); Shenzhen Science and Technology Innovation Program (JCYJ20220818095818040); National Natural Science Foundation of China (82103940); Basic and Applied Basic Research Foundation of Guangdong Province (2021A1515012503); Postdoctoral Research Foundation of China (2021M692903); National Natural Science Foundation of China (82304228); National Natural Science Foundation of China (81973152); Shenzhen Science and Technology Innovation Program (JCYJ20210324093612032); National Natural Science Foundation of China (82073646)
Based on 4 listed funder(s).
Publication
- Published
- 2025-09-23 · Arch Cardiovasc Dis · vol. 119 · issue 3 · pp. 216–232
- Publisher
- Elsevier BV
- Cited
- 1 citation · more than 47% of similar papers · 0.3× the field average
- References
- 71 works
- Access
- Paywalled
- Research areas
- Nuts composition and effects · Botany, Ecology, and Taxonomy Studies · Antioxidant Activity and Oxidative Stress
- Keywords
- Nut, Prospective cohort study, Disease, Consumption (sociology), Cohort study, Epidemiology, Risk factor, Atherosclerotic cardiovascular disease
- MeSH
- humans, nuts, cardiovascular diseases, prognosis, cause of death, risk assessment, risk factors, nutritive value, time factors, adult, aged, middle aged, female, male, protective factors, diet, healthy, heart disease risk factors
12 authors
From CN
- Mengna LiuZhengzhou University
- Mengmeng WangZhengzhou University
- Xueru FuZhengzhou University
- Xinxin HeZhengzhou University
- Mengdi WangZhengzhou University
- Yijia SuZhengzhou University
Abstract
Background
Evidence for the effects of nut consumption on cardiovascular disease (CVD) events and all-cause mortality has been reported inconsistently.
Aims
To assess the associations between nut consumption and CVD events and all-cause mortality.
Methods
We searched the Web of Science, Embase and PubMed up until 24 October 2023. In order to compute relative risks (RRs) and 95% confidence intervals (CIs), random-effects models were employed. Restricted cubic splines were performed to explore potential linear or non-linear associations. Heterogeneity was assessed (Cochran Q statistic) and quantified (I2-statistic). NutriGrade assessed the certainty of the evidence.
Results
Thirty-three publications (63 studies) were included. Comparisons between individuals with the highest versus lowest intake of nuts resulted in RRs (95% CIs) for coronary heart disease (CHD), stroke, CVD, CVD mortality and all-cause mortality of 0.81 (0.75-0.87), 0.91 (0.84-0.99), 0.86 (0.82-0.91), 0.74 (0.70-0.78) and 0.77 (0.73-0.81), respectively. With per 28-g increases in weekly nut intake, the RRs (95% CIs) for CHD, stroke, CVD, CVD mortality and all-cause mortality were 0.96 (0.95-0.97), 0.99 (0.97-1.01), 0.98 (0.97-0.99), 0.90 (0.86-0.94) and 0.92 (0.90-0.94), respectively. Nut intake was linearly associated with incidence of stroke (Pnon-linearity=0.691), CVD (Pnon-linearity=0.101) and CVD mortality (Pnon-linearity=0.069) and non-linearly associated with CHD (Pnon-linearitynon-linearity<0.001).
Conclusions
This systematic review and meta-analysis revealed an association between nut consumption and reduced risk of CVD and all-cause mortality. It highlighted the importance of nuts as a dietary supplement in the primary prevention of CVD and all-cause mortality.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.