Consumption of Unprocessed and Ultraprocessed Foods in Adolescents with Obesity: Associations with Neuroendocrine Mediators of Appetite Regulation and Binge Eating Symptoms
Neres PS, Ganen AP, Campos RMDS, Carvalho Ferreira JP, Oyama LM, Dâmaso AR, Masquio DCL
Nutrients · 0 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- University or hospital
- Universidade de São Paulo
- Government
- National Council for Scientific and Technological Development
- Government
- Coordenação de Aperfeicoamento de Pessoal de Nível Superior
- Grants
- Fundação de Amparo à Pesquisa do Estado de São Paulo (11/50356-0); Fundação de Amparo à Pesquisa do Estado de São Paulo (11/50414-0); Conselho Nacional de Desenvolvimento Científico e Tecnológico (305240/2021-8); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES AUX-PE-PNPD 2566/2011); Fundação de Amparo à Pesquisa do Estado de São Paulo (06/00684-3); Fundação de Amparo à Pesquisa do Estado de São Paulo (08/53069-0); Fundação de Amparo à Pesquisa do Estado de São Paulo (2013/041364); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 305240/2021-8)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2025-11-26 · Nutrients · vol. 17 · issue 23 · p. 3711
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 1 citation · more than 64% of similar papers · 0.4× the field average
- References
- 40 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Regulation of Appetite and Obesity · Eating Disorders and Behaviors · Biochemical Analysis and Sensing Techniques
- Keywords
- Ghrelin, Appetite, Binge eating, Obesity, Anthropometry, Peptide YY, Body mass index, Hormone, Consumption (sociology)
- MeSH
- humans, hypothalamic hormones, leptin, pituitary hormones, alpha-msh, melanins, neuropeptide y, diet, cross-sectional studies, feeding behavior, bulimia, body composition, appetite regulation, adolescent, brazil, female, male, agouti-related protein, ghrelin, binge-eating disorder, fast foods, pediatric obesity
7 authors
From BR
- Patrícia Sousa NeresCentro Universitário São Camilo
- Aline de PianoCentro Universitário São Camilo
- Raquel Munhoz da Silveira CamposUniversidade Federal de São Paulo
- Joana Pereira de Carvalho‐FerreiraUniversidade Estadual de Campinas (UNICAMP)
- Lila Missae OyamaUniversidade Federal de São Paulo
- Ana Raimunda DâmasoUniversidade Federal de São Paulo
Abstract
Background/Objectives: Obesity is a multifactorial disease associated with increased consumption of ultraprocessed foods and reduced intake of unprocessed foods. Binge eating, one of the most prevalent eating disorders among adolescents, is closely linked to obesity. Food intake is regulated by both the hedonic system, responsible for reward responses, and the physiological system, which controls hunger and satiety through hormones, such as ghrelin and leptin. The present study aimed to investigate associations between the intake of unprocessed and ultraprocessed foods, neuroendocrine mediators of appetite regulation, and binge eating in adolescents with obesity. Methods: This cross-sectional study included 96 adolescents with obesity who were recruited in São Paulo, Brazil, between 2010 and 2012. Anthropometric and body composition assessments were performed. Binge eating symptoms were evaluated using the binge eating scale (BES), and dietary intake was assessed with a validated Food Frequency Questionnaire, with items classified according to the Nova system. Frequency data were converted into annual consumption scores. Serum levels of ghrelin, leptin, neuropeptide Y (NPY), agouti-related peptide (AgRP), melanin-concentrating hormone (MCH), and alpha-melanocyte-stimulating hormone (α-MSH) were analyzed. Results: Lower consumption of unprocessed foods was associated with higher ghrelin concentrations (p = 0.023), accompanied by a greater percentage of body fat (p = 0.047) and a reduced percentage of lean mass (p = 0.047) compared with adolescents in the second tertile. AgRP was a positive predictor of annual consumption score of ultraprocessed food (β = 0.30; p = 0.04), independent of age, body fat, and binge eating symptoms. Conclusions: In conclusion, lower intake of unprocessed foods was associated with alterations in orexigenic and anorexigenic mediators, suggesting that dietary patterns in adolescents with obesity may influence the neuroendocrine mediators of appetite regulation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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