Egg Consumption and Cognitive Function: A Systematic Review and Dose-Response Pooled Analysis Exploring Optimal Daily Intake
Liu J, Shen Q, Wang X
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 0 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Peking University
- University or hospital
- Innovation Fund for Outstanding PhD Candidates of Peking University Health Science Centre
Based on 2 listed funder(s).
Publication
- Published
- 2026-01-06 · J Hum Nutr Diet · vol. 39 · issue 1 · p. e70198
- Publisher
- Wiley
- Cited
- 2 citations · more than 93% of similar papers · 5.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 62 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Nutrition and Health in Aging · Child Nutrition and Water Access
- Keywords
- Pooled analysis, Cognition, Consumption (sociology), Food intake, Meta-analysis, Food consumption
- MeSH
- humans, diet, longitudinal studies, cross-sectional studies, cognition, eating, eggs, aged, middle aged, female, male, cognitive dysfunction
3 authors
From CN
- J LiuPeking University
- Qingqing ShenLinyi University
- Xinxin Wang · correspondingLinyi University
Abstract
Background
Eggs provide a high amount of protein and micronutrients. However, the effects of egg intake on cognitive function remain inconclusive, and there has not yet been a pooled analysis on this topic.
Methods
Literature was searched from EMBASE, PubMed, MEDLINE, Web of Science, and Scopus database until 11 November 2025. Pooled risk ratios (RRs) were calculated utilising random-effects models. The heterogeneity among studies was evaluated using Q and I2 statistics. Subgroup analysis and meta-regression were used to assess the impact of ages, follow-up years of longitudinal studies, diet assessment and risk of bias. Sensitivity analyses were conducted to evaluate the robustness, and publication bias was assessed through Egger's tests. Dose-response relationships were explored through a one-stage robust error meta-regression model. This systematic review and meta-analysis were registered at PROSPERO (No. CRD42024613229).
Results
We identified 13 longitudinal and 8 cross-sectional studies, comprising 99,453 individuals with 18,893 cases mainly from Asian countries and the United States. Egg consumption closest to 50 g/day was longitudinally linked to a lower risk of cognitive decline (pooled RR = 0.91; 95%CI = 0.83-0.99), and a 'U-shaped' dose-response relationship was also observed at the lowest risks occurring at 50-60 g/day of egg. Stratified by ages, follow-up years, study population and egg intake assessment, the similar 'U-shaped' relationships were also observed. No publication bias was detected.
Conclusion
One egg/day (50-60 g/day) is necessary to maintain healthy cognition function in elderly, which may be an effective food therapy to alleviate cognitive decline.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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