Omega-3 fatty acids and cardiovascular risk-related metabolic markers in diverse populations: a meta-analysis of randomized trials
Chen C, Li X, Yan H, Liu J, Cao Y, Zhao H, Liu S, Wang Y, Sun Y, Jia B, Yuan J
Nutrition, metabolism, and cardiovascular diseases : NMCD · 0 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National College Students Innovation and Entrepreneurship Training Program
- Government
- Shandong Provincial Postdoctoral Science Foundation
- Grants
- Shandong Provincial Postdoctoral Science Foundation (SDCX-ZG-202400024); National Natural Science Foundation of China (82100854); National College Students Innovation and Entrepreneurship Training Program (202411065024)
Based on 3 listed funder(s).
Publication
- Published
- 2025-12-03 · Nutr Metab Cardiovasc Dis · vol. 36 · issue 4 · p. 104488
- Publisher
- Elsevier BV
- Cited
- 2 citations · more than 59% of similar papers · 0.5× the field average
- References
- 53 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases · Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Randomized controlled trial, Metabolic syndrome, Cardiovascular health, Polyunsaturated fatty acid, Triglycerides blood, Clinical trial
- MeSH
- humans, cardiovascular diseases, lipids, fatty acids, omega-3, treatment outcome, risk assessment, oxidative stress, dietary supplements, adult, aged, middle aged, female, male, dyslipidemias, adiponectin, randomized controlled trials as topic, young adult, biomarkers, heart disease risk factors, cardiometabolic risk factors
11 authors
From CN
- Chen ChenQingdao University
- Xuan LiQingdao University; Qingdao Municipal Hospital
- Hongli YanQingdao University
- Junyan LiuQingdao University
- Yuhang CaoQingdao University
- Hongjiao ZhaoQingdao University
Abstract
Aim
Many studies reported the effects of n-3 polyunsaturated fatty acids (PUFA) towards cardiovascular risk, but results are inconclusive. This meta-analysis systemically explored PUFA-mediated effects on representative cardiovascular-related metabolic markers, including glycolipid profile, adiponectin, and oxidative stress indicators in different people.
Data synthesis
Literature search on PubMed, EMBASE, Web of Science, and the Cochrane Library were performed up to October 11, 2024. Randomized controlled trials focusing on the effects of n-3 PUFA supplementation on triacylglycerol (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), apolipoprotein, adipokine, hemoglobin A1c (HbA1c), c-reactive protein (CRP), and oxidative stress biomarkers were chosen as outcome variables. There were 24 studies with 2043 subjects showed significant effects: (1)TG decreased by 16.95 mg/dl (21 trials, n = 1491; 95 % CI: 23.25, -10.66), (2)HDL increased by 1.55 mg/dl (22 trials, n = 1914; 95 % CI: 0.69, 2.42), (3)adiponectin increased by 0.96 μg/ml (3 trials, n = 198; 95 % CI: 0.03, 1.8), (4)HbA1c decreased by 0.17 % (3 trials, n = 283; 95 % CI: 0.29, -0.04), (5)LDL decreased by 10.98 mg/dl in women (4 trials, n = 236; 95 % CI: 19.41, -2.5) and by 13.77 mg/dl in the polycystic ovary syndrome (PCOS) (3 trials, n = 180; 95 % CI: 22.83, -4.7), (6)TC decreased by 15.58 mg/dl in women (4 trials, n = 236; 95 % CI: 24.64, -6.53).
Conclusions
The meta-analysis indicates that n-3 PUFAs improve cardiovascular-related metabolic markers, potentially benefit cardiovascular health in patients with cardiovascular disease, PCOS, and kidney disease, especially in older women via reducing TG and HbA1c and increasing HDL and adiponectin.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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