Study2026

Repeated Low-Level Red-Light Therapy for Myopia Control in Myopic Anisometropia Children and Adolescents

Yu Y, Ma N, Jie H

Ophthalmic epidemiology · 0 citations

Review labels

Funding not disclosed

Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.

How it was studied

Design
Cohort study (classified by our AI screen)
Studied in
People
Main outcome
Health markers and function

Who paid for it

Funding
Funding not disclosed

Publication

Published
2026-02-10 · Ophthalmic Epidemiol · vol. 33 · issue 3 · pp. 283–291
Publisher
Taylor & Francis
Cited
0 citations · more than 10% of similar papers · 0.0× the field average
References
28 works
Access
Paywalled
Research areas
Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Ocular Surface and Contact Lens
Keywords
Anisometropia, Vision disorder, Refractive error, Visual acuity, Population
MeSH
humans, anisometropia, myopia, refraction, ocular, phototherapy, follow-up studies, visual acuity, adolescent, child, female, male, axial length, eye, red light

3 authors

From CN

  • Yixian YuWuhan Children's Hospital
  • Nan MaWuhan Children's Hospital
  • Hong Jie · correspondingWuhan Children's Hospital

Abstract

Purpose

To evaluate the efficacy of repeated low-level red-light (RLRL) therapy for myopia control in children and adolescents with myopic anisometropia.

Methods

Between January 2022 and October 2023, a total of 52 participants diagnosed with myopic anisometropia were enrolled in the study. The participants underwent RLRL therapy, administered via a device emitting red light at a wavelength of 650 nm. Each participant received the treatment for a duration of one year and underwent examinations at baseline, 3-, 6-, and 12-months. The follow-up period concluded by October 2024.

Results

More myopic eye refers to the eye with a higher (more negative) spherical equivalent (SE) value as measured by refractive examination, the contralateral eye is the less myopic eye. Cycloplegic spherical equivalence refraction (SER) of more myopia eyes changed from -4.47 ± 2.37D to -4.40 ± 2.37D (p = 0.005). However, SER of less myopic eyes between baseline and 12-month showed no significant difference (-2.59 ± 2.15D versus -2.50 ± 2.14D, p = 0.061). Axial length (AL) of more myopic eyes decreased more (25.42 ± 1.29 mm versus 25.17 ± 1.21 mm, p p p = 0.046) and SER status (p = 0.023). No other correlation was found among sex, age, and change of AL or SER.

Conclusions

RLRL therapy has emerged as a promising therapeutic approach for addressing myopia anisometropia. Notably, eyes with greater degrees of myopia exhibit more pronounced benefits, including AL shortening and reversal of SER progression.

Abstract via Europe PMC. Copyright remains with the authors or publisher.

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