Acute measurement of flow-mediated dilation following passive heating in adults: The confounding role of altered shear stress and baseline vasodilation
Menzies C, Clarke ND, Steward CJ, Thake CD, Pugh CJA, Cullen T
Physiological reports · 1 citation
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Coventry University
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2026-02-01 · Physiol Rep · vol. 14 · issue 4 · p. e70723
- Publisher
- Wiley
- Cited
- 0 citations · more than 12% of similar papers · 0.0× the field average
- References
- 28 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Cardiovascular Health and Disease Prevention · Infrared Thermography in Medicine
- Keywords
- Brachial artery, Vasodilation, Confounding, Dilation (metric space), Occlusion, Baseline (sea), Acute exposure, Allometry
- MeSH
- brachial artery, humans, regional blood flow, vasodilation, stress, mechanical, adult, female, male, hot temperature, young adult
6 authors
From GB
- Campbell Menzies · correspondingUniversity of Nottingham; Coventry University
- Neil David ClarkeBirmingham City University
- Charles James StewardUniversity of Nottingham; Coventry University
- C. Douglas ThakeCoventry University
- Christopher J. A. PughCardiff Metropolitan University
- Tom CullenCoventry University
Abstract
Changes in flow-mediated dilation (FMD) following acute heating are not well understood, appear protocol-specific, and may be better understood by additional measures of acute vasoactivity. This study investigated FMD responses before and after three different 30-min hot-water immersion conditions (40°C-Shoulder, 42°C-Waist, and 40°C-Waist) in 22 adults. Brachial artery diameter was recorded at baseline (Dbase), during the final 30 s of occlusion (Docc), and at peak post-occlusion (Dpeak). Allometrically scaled FMD%, and changes in diameter during occlusion (OIV), and from end-occlusion to peak diameter (FMDDocc) were calculated. Pre-occlusion shear rate was greater post-immersion in 40-Shoulder (p base increased (Δ0.4 ± 0.2 mm, p base (rrm = -0.47, p = 0.001). OIV% was the only vasoactivity metric to statistically differentiate between all conditions post-immersion (40°C-Shoulder: -8.1 ± 4.9%. 42°C-Waist: -3.0 ± 5.3%. 40°C-Waist: 1.1 ± 4.1%. p < 0.001). Post-heating FMD is confounded by heat-induced increases in baseline diameter, even after allometric scaling, while OIV% may provide complementary insight into acute vasoactivity following passive heating.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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