Acute kidney injury biomarker responses in young and older female adults following mild hypohydration
Domeier C, Robinson AT, Babcock MC, Vondrasek JD, Bissen TG, Muñoz CX, Smith KA, Watso JC
American journal of physiology. Renal physiology · 2 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Heart Association
- University or hospital
- Florida State University
- Government
- National Institutes of Health
- Nonprofit
- American Heart Association (AHA)
- Nonprofit
- Institute for Successful Longevity
- Government
- NHLBI NIH HHS
- Government
- HHS | National Institutes of Health
- Government
- HHS | National Institutes of Health (NIH)
- Government
- NIDDK NIH HHS
- Grants
- American Heart Association (25PRE1354834); American Heart Association (23CDA1037938); National Institutes of Health (K01 HL147998); National Institutes of Health (K01HL164978); National Institutes of Health (K01 HL160772)
Based on 9 listed funder(s).
Publication
- Published
- 2026-02-27 · Am J Physiol Renal Physiol · vol. 330 · issue 4 · pp. F456–F466
- Publisher
- American Physical Society
- Cited
- 2 citations · more than 97% of similar papers · 9.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Open access (repository copy)
- Research areas
- Thermoregulation and physiological responses · Acute Kidney Injury Research · Electrolyte and hormonal disorders
- Keywords
- Renal function, Biomarker, Cystatin C, Urine, Urinary system, Acute kidney injury, Urine osmolality, Excretion
- MeSH
- kidney, humans, dehydration, insulin-like growth factor binding proteins, tissue inhibitor of metalloproteinase-2, cross-over studies, water deprivation, age factors, renin-angiotensin system, aging, osmolar concentration, adult, aged, middle aged, female, cystatin c, young adult, acute kidney injury, biomarkers, lipocalin-2
8 authors
From US
- Christin DomeierFlorida State University
- Austin T. RobinsonIndiana University
- Matthew C. BabcockUniversity of Colorado Anschutz
- Joseph D. VondrasekFlorida State University
- Thomas G. BissenFlorida State University
- Colleen X. MuñozUniversity of Hartford
Abstract
Hypohydration reduces kidney function and increases acute kidney injury (AKI) risk. Aging increases hypohydration-induced kidney dysfunction in males, but female aging studies are lacking. Therefore, we compared the effects of mild hypohydration on kidney function and AKI biomarkers in young (YF) and older female adults (OF). In a random crossover design, 17 YF (20-35 yr old) and 9 OF (55-75 yr old), who were apparently healthy, completed two hydration protocols with ≥1 wk washout: 1) baseline hydration, and 2) stepwise water restriction over 3 days, concluding with 16 h water deprivation. We assessed hydration, AKI biomarkers, and the renin-angiotensin-aldosterone system (RAAS) from blood and 24-h urine samples. The effects of age group and condition were assessed using two-way mixed-effects analysis and reported as means ± SD. Hypohydration increased urine specific gravity and osmolality (condition effect: P P = 0.04), independent of age (P = 0.62). Urine cystatin C excretion increased in YF (P P = 0.69), with a significant interaction effect (P = 0.017). Nephrin excretion and product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2 (IGFBP7 × TIMP-2) increased after hypohydration (both P P ≥ 0.35). OF exhibited lower plasma renin activity than YF (P = 0.046), with no other main or interaction effects for other RAAS markers. OF did not exhibit greater AKI biomarker responses to mild hypohydration, contrasting with male studies showing age-related kidney function decline. These results highlight the need for research to clarify potential sex-based differences in age-related decline in kidney function.NEW & NOTEWORTHY This is the first study to assess the effects of mild hypohydration on acute kidney injury biomarkers in young and older female adults. Mild hypohydration altered acute kidney injury biomarker concentrations in both age groups, with no observed age-related differences, contrasting with male studies that show an age-related decline. These findings highlight the need for targeted research on potential sex-related differences in kidney function decline with aging.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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