Vitamin D Status and Supplementation in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Huang S, Li X, Wu H, Chen X, Wu X, Huang Z, Chang L, Zhang Y, Li Y, Zhang G
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 0 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Guangdong Province
- Government
- Guangzhou Municipal Science and Technology Project
- Grants
- Natural Science Foundation of Guangdong Province (2023A1515012430); Guangzhou Municipal Science and Technology Project (2023A03J0208); National Natural Science Foundation of China (82271145); National Natural Science Foundation of China (82101196：82101194); National Natural Science Foundation of China (82301283)
Based on 3 listed funder(s).
Publication
- Published
- 2026-03-03 · Otolaryngol Head Neck Surg · vol. 174 · issue 5 · pp. 1135–1145
- Publisher
- Wiley
- Cited
- 1 citation · more than 85% of similar papers · 3.4× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Sinusitis and nasal conditions · Vitamin D Research Studies · Salivary Gland Disorders and Functions
- Keywords
- Vitamin D and neurology, Disease, vitamin D deficiency, Clinical trial, Diabetes mellitus
- MeSH
- humans, chronic disease, vitamins, vitamin d, dietary supplements, rhinosinusitis
10 authors
From CN
- ShuYi HuangSun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- X. LiSun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Haotian WuSun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Xiaohong ChenSun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Xifu WuSun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
- Zizhen HuangSun Yat-sen University; Third Affiliated Hospital of Sun Yat-sen University
Abstract
Objectives
To investigate the relationship between vitamin D (VD) levels and chronic rhinosinusitis (CRS), and to evaluate the therapeutic efficacy of VD supplementation for CRS.
Data sources
Two independent reviewers systematically searched PubMed, Embase, and the Cochrane Library to identify studies that assessed the association between CRS and VD, as well as the therapeutic effects of VD supplementation on CRS outcomes.
Review methods
Meta-analyses were conducted to compare VD levels between CRS patients and controls and to evaluate the efficacy of VD supplementation. Random- or fixed-effects models were applied as appropriate. Sensitivity and subgroup analyses were performed to investigate potential sources of heterogeneity.
Results
A pooled analysis of 15 studies showed significantly lower serum VD levels in CRS patients compared to controls (SMD = -0.98; P < .001). Both 25(OH)D3 and 25(OH)D assays showed lower VD levels in CRS patients (SMD = -1.24, P < .001 vs SMD = -0.77, P < .001). Subgroup analyses also revealed consistent reductions in both CRS with nasal polyps (CRSwNP; SMD = -1.05; P < .001) and CRS without nasal polyps (CRSsNP; SMD = -1.02; P < .001). Moreover, four randomized controlled trials indicated that VD supplementation significantly improved Sino-Nasal Outcome Test-22 (SNOT-22) scores at <3 months (MD = -1.44; P = .001); however, this benefit was not maintained at ≥3 months (MD = -6.52; P = .12).
Conclusions
CRS patients show significantly lower serum VD levels than healthy controls. VD supplementation may provide short-term symptomatic improvement, although its long-term efficacy remains unproven.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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