Funded in part by Fundación Mutua Madrileña, Mutua Madrileña Foundation, Caixabank SA
Ultraprocessed foods consumption and risk of preeclampsia: a secondary analysis of the improving mothers for a better prenatal care trial Barcelona (IMPACT BCN) randomized clinical trial
Trejo-Domínguez A, Benitez L, Crovetto F, Casas R, Youssef L, Larroya M, Ruiz-León AM, Nakaki A, Genero M, Casas I, Novoa RH, Encabo N, Rahman M, Wang X, O'Sullivan JF, Hegarty NR, Vieta E, Gratacós E, Estruch R, Crispi F, Castro-Barquero S
The American journal of clinical nutrition · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Company
- Fundación Mutua Madrileña
- Nonprofit
- “la Caixa” Foundation
- Nonprofit
- Broach Foundation for Brain Cancer Research
- Nonprofit
- National Heart Foundation of Australia
- Government
- Instituto de Salud Carlos III
- Company
- Mutua Madrileña Foundation
- Government
- Carlos III Health Institute
- Company
- Caixabank SA
- Authors
- At least one author declares a financial tie to industry
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2026-03-02 · Am J Clin Nutr · vol. 123 · issue 5 · p. 101255
- Publisher
- Elsevier BV
- Cited
- 1 citation · more than 94% of similar papers · 7.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Sodium Intake and Health · Nutrition and Health Studies
- Keywords
- Consumption (sociology), Randomized controlled trial, Quality (philosophy), Population, Risk assessment
- MeSH
- humans, pre-eclampsia, prenatal care, diet, risk factors, pregnancy, adult, infant, newborn, spain, female, young adult, food, processed, secondary data analysis
21 authors
From ES, AU
- Alejandra Trejo-DomínguezHospital Sant Joan de Déu Barcelona
- Leticia BENITEZHospital Sant Joan de Déu Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- F. Crovetto · correspondingHospital Sant Joan de Déu Barcelona
- Rosa Casas · correspondingCentro de Investigación Biomédica en Red
- L. YoussefHospital Sant Joan de Déu Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Marta LarroyaHospital Sant Joan de Déu Barcelona; Hospital Universitario Dexeus
Abstract
Background
Preeclampsia is a pregnancy-specific condition affecting 2%-8% of pregnant females and a leading cause of maternal and perinatal morbimortality. High ultraprocessed food (UPF) consumption has been associated with the development of noncommunicable chronic diseases, but evidence on pregnancy outcomes is scarce.
Objectives
To study the association of maternal UPF consumption and the risk of preeclampsia.
Methods
This study is a secondary analysis of the IMPACT BCN, a randomized clinical trial including 1221 pregnant females at high risk for small for gestational age newborns, conducted in Barcelona, Spain. Among these, 812 participants with complete dietary data at 2 timepoints during pregnancy (between weeks 19-23 of gestation and weeks 34-36 of gestation) were included in this analysis and classified into tertiles of change in UPF consumption during pregnancy. Dietary UPF consumption was assessed using NOVA classification with a validated 151-item food frequency questionnaire. Preeclampsia was defined as high blood pressure plus targeted organ involvement. Analyses were performed using logistic regression models adjusted for potential confounding factors.
Results
Associations between change of UFP consumption during pregnancy and overall preeclampsia were observed across tertiles [odds ratio (OR)T3 compared with T1: 2.29; 95% confidence interval (CI): 1.06, 4.97, P-trend 0.026], but not when UPF change was modeled as a continuous variable [OR: 1.04; 95% CI: 0.95, 1.14]. Among UPF subclasses, pre-prepared dishes were significantly associated with preeclampsia risk [ORT3 compared with T1: 2.36; 95% CI: 1.09, 5.12].
Conclusions
In a high-risk population, a higher change in dietary intake of UPF consumption from the second to third trimester of pregnancy was associated with a higher risk of preeclampsia. This trial was registered at clinicaltrials.gov as NCT03166332.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.