Funded in part by Egg Nutrition Center
Egg Intake and the Incidence of Alzheimer's Disease in the Adventist Health Study-2 Cohort Linked with Medicare Data
Oh J, Oda K, Chiriac G, Fraser GE, Sirirat R, Sabaté J
The Journal of nutrition · 1 citation
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Industry group
- Egg Nutrition Center
- Government
- National Cancer Institute
- Government
- National Institutes of Health National Cancer Institute
- Grants
- National Cancer Institute (1U01CA152939)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2026-04-17 · J Nutr · vol. 156 · issue 6 · p. 101541
- Publisher
- Elsevier BV
- Cited
- 2 citations · more than 99% of similar papers · 15.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 28 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Food composition and properties · Alzheimer's disease research and treatments
- Keywords
- Hazard ratio, Proportional hazards model, Cohort, Incidence (geometry), Cohort study, Disease, Confidence interval, Prospective cohort study, Nutrient
- MeSH
- humans, alzheimer disease, diet, incidence, proportional hazards models, risk factors, cohort studies, prospective studies, life style, eggs, aged, aged, 80 and over, medicare, united states, female, male
6 authors
From US
- Jisoo Oh · correspondingLoma Linda University; Loma Linda University Health Care
- Keiji OdaLoma Linda University; Loma Linda University Health Care
- Gabriela ChiriacLoma Linda University; Loma Linda University Health Care
- Gary E. FraserLoma Linda University; Loma Linda University Health Care
- Rawiwan SiriratLoma Linda University; Loma Linda University Health Care
- Joan SabatéLoma Linda University
Abstract
Background
A substantial knowledge gap remains regarding the relationship between modifiable dietary factors and Alzheimer's disease risk. Eggs are a source of key nutrients that support brain health.
Objectives
The aim of this study was to investigate the association between egg consumption and the incidence of Alzheimer's disease.
Methods
Data were drawn from the Adventist Health Study-2, a large, prospective cohort of United States Seventh-day Adventists, linked with Medicare records to identify Alzheimer's disease diagnosis. Diet and lifestyle factors were assessed using a validated food frequency questionnaire. Egg consumption was categorized by frequency, ranging from never/rarely to ≥5 times per week. The analytic sample included 39,498 participants (mean follow-up: 15.3 y), among whom 2858 developed Alzheimer's disease. Multivariable-adjusted Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analysis was conducted using continuous egg intake (g/d).
Results
Egg consumption was inversely associated with Alzheimer's disease risk. Compared with never/rarely consuming eggs, HRs (95% CIs) after adjusting for demographic, lifestyle, food groups, and comorbidities were 0.83 (0.75, 0.92) for 1-3 times per month, 0.83 (0.74, 0.94) for once per week, 0.80 (0.71, 0.90) for 2-4 times per week, and 0.73 (0.60, 0.89) for ≥5 times per week. In the spline model, zero egg intake was curvilinearly associated with an adjusted HR of 1.22 (1.11, 1.34) compared with 10 g/d.
Conclusions
In this health-conscious population, moderate egg consumption was associated with a significantly lower risk of Alzheimer's disease. These findings suggest a potential neuroprotective benefit of nutrients found in eggs when consumed as part of a balanced diet.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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