Effect of Polyphenol-Rich Diet Combined with Leucine, Vitamin D3, and Magnesium Supplementation on Self-Reported Mobility and Health Perception in Adults at Risk of Sarcopenia: A 3-Months Quasi-Experimental Study
Tache-Codreanu DL, Tache-Codreanu AM, Stefan G, Trăistaru MR, Rusu E, Tache-Codreanu A, Sporea C
Life (Basel, Switzerland) · 1 citation
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2026-03-27 · Life (Basel) · vol. 16 · issue 4 · p. 554
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 1 citation · more than 93% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 59 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutrition and Health in Aging · Muscle Physiology and Disorders · Muscle metabolism and nutrition
- Keywords
- Context (archaeology), Sarcopenia, Rehabilitation, Vitamin D and neurology, Muscle strength, Correlation, Perception, Vitamin, Vitamin C
9 authors
From RO
- Diana-Lidia Tache-CodreanuTitu Maiorescu University; Spitalul Clinic Colentina
- Ana-Maria Tache-CodreanuCarol Davila University of Medicine and Pharmacy; National University of Theatre and Film I.L. Caragiale
- Ana-Maria Tache-Codreanu · correspondingCarol Davila University of Medicine and Pharmacy; National University of Theatre and Film I.L. Caragiale
- Georgeta Stefan · correspondingUniversity of Agronomic Sciences and Veterinary Medicine of Bucharest
- Magdalena Rodica TrăistaruUniversity of Medicine and Pharmacy of Craiova
- Elena Emanuela RusuTitu Maiorescu University
Abstract
Background
Sarcopenia is characterized by progressive muscle weakness, impaired physical function, and reduced quality of life. Multimodal strategies combining rehabilitation and nutritional support that influence gut microbiota may help improve functional outcomes in adults at risk of sarcopenia.
Objective
To evaluate whether a polyphenol-rich dietary recommendation associated with a nutritional supplement containing leucine, vitamin D3, and magnesium (SarcoDYN®), in the context of a standardized rehabilitation program, provides superior improvements in functional and patient-reported outcomes compared with rehabilitation alone.
Methods
This quasi-experimental, non-randomized retrospective study included 28 adults at risk of sarcopenia, divided into a study group (rehabilitation + polyphenol-rich diet + SarcoDYN®) and a control group (rehabilitation only). Assessments were performed at baseline and after 3 months. Outcomes included SARC-F score, handgrip strength (dominant and non-dominant), sit-to-stand performance, perceived mobility, and perceived health status. Within- and between-group comparisons were conducted using appropriate parametric or non-parametric tests, and Spearman correlation analysis explored associations between functional, strength, and perceptual variables.
Results
Both groups demonstrated significant within-group improvements in functional and patient-reported outcomes. At follow-up, the study group showed significantly better subjective outcomes, including lower SARC-F scores (U = 30.0, p = 0.002), higher perceived mobility (U = 40.0, p = 0.008), and higher perceived health status (U = 40.0, p = 0.008), compared with the control group. Objective post-intervention measures of handgrip strength and chair-rise performance did not differ significantly between groups. Correlation analysis revealed strong associations between SARC-F score, muscle strength, functional mobility, and perceived health.
Conclusions
The combined intervention consisting of a polyphenol-rich diet that influence gut microbiota and SarcoDYN® supplementation, delivered alongside a structured rehabilitation program, was associated with better patient-reported mobility and health perception in adults at risk of sarcopenia. These findings should be considered exploratory and hypothesis-generating, and require confirmation in larger controlled studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.