Hypohydration Increases Heart Rate Despite Preserved Hemodynamic Compensation During Blood Flow Restricted Exercise
Pignanelli C, Lydiate GC, Grigore MM, McCrone JC, Turetskiy K, Parris REJ, Bisset-Cavallin EM, Robertson AA, Gamble ASD, Millar PJ, Tymko MM, Burr JF
Scandinavian journal of medicine & science in sports · 0 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Natural Sciences and Engineering Research Council of Canada
- Grants
- Natural Sciences and Engineering Research Council of Canada (03974)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2026-05-01 · Scand J Med Sci Sports · vol. 36 · issue 5 · p. e70296
- Publisher
- Wiley
- Cited
- 0 citations · more than 38% of similar papers · 0.0× the field average
- References
- 59 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Thermoregulation and physiological responses · Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control
- Keywords
- Orthostatic vital signs, Stroke volume, Heart rate, Blood pressure, Blood volume, Hemodynamics, Cardiac output, Blood flow
- MeSH
- humans, dehydration, cardiac output, stroke volume, lower body negative pressure, exercise, walking, blood volume, blood pressure, heart rate, regional blood flow, adult, female, male, hemodynamics, orthostatic intolerance, young adult, blood flow restriction therapy
12 authors
From CA, IE
- Christopher PignanelliUniversity of Guelph
- Gavin C. LydiateUniversity of Guelph
- Monica M. GrigoreUniversity of Guelph
- Jenna C. McCroneUniversity of Guelph
- Katrin TuretskiyUniversity of Guelph
- Regan E. J. ParrisUniversity of Guelph
Abstract
During blood flow restriction (BFR) exercise, blood becomes sequestered in the active limbs due to impeded venous return, contributing to central hypovolemia. Dehydration also reduces blood volume and can exacerbate the ability of the cardiovascular (CV) system to defend against CV stressors, such as exercise and orthostatic stress. As BFR becomes more widely used, its application in individuals who may be suboptimally hydrated underscores the need to understand how hydration status influences cardiovascular strain. We tested whether hypohydration affects the CV response to BFR exercise and its relationship to orthostatic tolerance. Seventeen participants (7 females) performed a lower-body negative pressure test to assess orthostatic tolerance, and a bilateral BFR walking (5 km/h at 5% incline) bout under two conditions, counterbalanced: with regular fluid consumption (Hydrated), or after 24-h of fluid restriction (Hypohydrated). Heart rate, beat-to-beat blood pressure, and thoracic impedance were continuously measured, from which stroke volume and cardiac output were estimated. Hypohydration reduced body mass (-2.3% ± 0.7%, p 0.21). Orthostatic tolerance did not differ between conditions (354 ± 179 vs. 312 ± 128 mmHg•min, p = 0.17). The preservation of stroke volume, cardiac output, and orthostatic tolerance suggests that CV compensatory mechanisms during BFR exercise remain effective under mild hypohydration with the increased heart rate resulting from the manipulation of non-vascular fluid compartments.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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