Processed meat intake and gastric adenocarcinoma risk among adults in Central-West Brazil: a case-control study
Santiago SB, Silva ARC, Curado MP, Ramos AFPL, Bizinoto ALS, de Brito AM, Cardoso DMM, Milhomem LM, Fernandes GA, Barbosa MS
BMC nutrition · 0 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Grants
- Fundação de Amparo à Pesquisa do Estado de São Paulo (14/26897-0)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2026-05-14 · BMC Nutr · vol. 12 · issue 1
- Publisher
- BioMed Central
- Cited
- 0 citations · more than 36% of similar papers · 0.0× the field average
- References
- 31 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Colorectal Cancer Screening and Detection · Gastric Cancer Management and Outcomes · Helicobacter pylori-related gastroenterology studies
- Keywords
- Odds ratio, Processed meat, Confidence interval, Logistic regression, Clinical nutrition, Risk factor, Food intake, Gastric adenocarcinoma
10 authors
From BR
- Silvana Barbosa Santiago · correspondingUniversidade Federal de Goiás
- Alex Richard Costa SilvaAC Camargo Hospital
- María Paula CuradoAC Camargo Hospital; Universidade Federal de Goiás
- Amanda Ferreira Paes Landim RamosUniversidade Federal de Goiás
- Ana Luísa Santos BizinotoUniversidade Federal de Goiás
- Alexandre Menezes de BritoHospital Araújo Jorge
Abstract
Background
Processed meat is classified as a Group 1 carcinogen; however, evidence from Latin America-particularly Brazil-regarding its role in gastric adenocarcinoma (GA) remains limited. We examined the association between processed meat intake of GA among adults in Brazil's Central-West region.
Methods
This case-control study included 553 participants (166 cases, 189 endoscopic controls, and 198 hospital controls). Processed meat intake was assessed using a validated food frequency questionnaire. Associations were estimated using logistic regression models, calculating odds ratios (OR) and 95% confidence intervals (95% CI) for each 10 g/day increment in processed meat consumption. Adjusted predicted probabilities were estimated using post-estimation marginal effects to evaluate dose-response patterns across an intake range of 0-40 g/day.
Results
Higher processed meat intake was associated with an increased risk of GA in both comparisons, with an OR of 1.53 (95% CI: 1.09-2.15) using endoscopic controls and an OR of 1.28 (95% CI: 1.02-1.61) using hospital controls. Predictive margins showed an approximately linear dose-response pattern.
Conclusion
These findings provide evidence from an understudied Brazilian region and suggest processed meat intake as a potentially modifiable risk factor for GA.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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